Visible-Light-Induced Synthesis of γ-Amino Sulfones from Vinyl Sulfones and Amino Acids

被引：1
|
作者：
Qian, Zhu-Ming [1 ]
Wang, Feng-Yu [1 ]
Guan, Zhi [1 ]
He, Yan-Hong [1 ]
机构：
[1] Southwest Univ, Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal, Chongqing 400715, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 13期
基金：
中国国家自然科学基金;
关键词：
photochemistry; gamma-amino sulfone; vinyl sulfone; amino acid; decarboxylation; FUNCTIONALIZATION; DERIVATIVES; INHIBITORS; RADICALS;
D O I：
10.1002/adsc.202400432
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A method for the synthesis of gamma-amino sulfones through visible light-induced oxidative decarboxylation and radical reductive addition is described. Various readily available N-protected natural amino acids react with aromatic/aliphatic vinyl sulfones to directly produce gamma-amino sulfone derivatives. This reaction is also applicable to alpha-N(O)-acids and other aliphatic carboxylic acids, resulting in the corresponding sulfone derivatives. The method operates without the need for sacrificial reducing agents or additional hydrogen atom donors. The sole by-product is CO2 released from decarboxylation, rendering the process both atom- and step-economical. image
引用
收藏
页码：3022 / 3028
页数：7
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