Multifactorial Effects of COVID-19: A Review of Published Autopsy Reports
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作者:
Chawla, Karan
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Univ Toledo, Coll Med & Life Sci, Dept Med Microbiol & Immunol, Toledo, OH 43614 USAUniv Toledo, Coll Med & Life Sci, Dept Med Microbiol & Immunol, Toledo, OH 43614 USA
Chawla, Karan
[1
]
Hong, Stephen
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Univ Toledo, Coll Med & Life Sci, Dept Med Microbiol & Immunol, Toledo, OH 43614 USAUniv Toledo, Coll Med & Life Sci, Dept Med Microbiol & Immunol, Toledo, OH 43614 USA
Hong, Stephen
[1
]
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Shields, Ryan
[1
]
Ford, Alexandra
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Univ Toledo, Coll Med & Life Sci, Dept Med Microbiol & Immunol, Toledo, OH 43614 USAUniv Toledo, Coll Med & Life Sci, Dept Med Microbiol & Immunol, Toledo, OH 43614 USA
Ford, Alexandra
[1
]
Pacella, Gioia
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机构:
John Carroll Univ, Dept Biol, University Hts, OH 44118 USAUniv Toledo, Coll Med & Life Sci, Dept Med Microbiol & Immunol, Toledo, OH 43614 USA
Pacella, Gioia
[2
]
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Lurie, Fedor
[3
,4
]
机构:
[1] Univ Toledo, Coll Med & Life Sci, Dept Med Microbiol & Immunol, Toledo, OH 43614 USA
[2] John Carroll Univ, Dept Biol, University Hts, OH 44118 USA
COVID-19;
SAR-CoV-2;
cause of death;
autopsy;
ACUTE RESPIRATORY SYNDROME;
HISTOPATHOLOGICAL FINDINGS;
ULTRASTRUCTURAL FINDINGS;
FATAL COVID-19;
PATHOLOGY;
INFECTIONS;
INFLUENZA;
PROTEIN;
H5N1;
D O I:
10.3390/covid2050041
中图分类号:
R1 [预防医学、卫生学];
学科分类号:
1004 ;
120402 ;
摘要:
We systematically reviewed published data on autopsies of patients who died from COVID-19 to identify pathological changes that are consistently reported in autopsies and those that were reported anecdotally, and to compare consistent findings with autopsy findings in similar diseases. The MEDLINE, Google Scholar, and Embase databases were searched for full-text articles in the English language from December 2019 to March 2021 to include publications on autopsy findings in patients whose main cause of death was COVID-19 and COVID-19-related complications. This review included 124 published papers documenting COVID-19 patient autopsies for over 1100 patients. Most frequent and consistently reported pathological findings included diffuse alveolar damage in the lungs, cardiac inflammation, and hypertrophy, vascular microthrombi, shock kidney and acute tubular necrosis, congested liver and spleen, and shock-associated changes in other organs. These findings by themselves were not unique, and were similar to other severe viral infections and septic shock. However, the frequency of diffuse alveolar damage and the extent of microvascular thrombosis were much higher among the autopsies of patients who had died from COVID-19 compared with other severe viral infections. Autopsy data confirm clinical reports of high incidences of diffuse alveolar damage and microvascular thrombosis in the most severe cases of COVID-19 that caused death.
机构:
Army Med Univ, Initiating Member COVID19 Pathol Team, Inst Pathol, Southwest Hosp,Third Mil Med Univ, Chongqing, Peoples R China
Army Med Univ, Southwest Canc Ctr, Southwest Hosp, Third Mil Med Univ, Chongqing, Peoples R ChinaArmy Med Univ, Initiating Member COVID19 Pathol Team, Inst Pathol, Southwest Hosp,Third Mil Med Univ, Chongqing, Peoples R China
机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Buda, M. M.
Miguel, C.
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Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Miguel, C.
Estivariz, Z.
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机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Estivariz, Z.
Iglesias, E.
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机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Iglesias, E.
Santiago, N.
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机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Santiago, N.
Barriobero, N.
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机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Barriobero, N.
Martinez, A.
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机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Martinez, A.
Perez Rodriguez, A.
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机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Perez Rodriguez, A.
Bugallo, A.
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机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Bugallo, A.
Aguilera, A.
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机构:
Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
Aguilera, A.
Guerra, I.
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Araba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, SpainAraba Univ Hosp, Bioaraba Hlth Res Inst, OSI Araba, Clin Dept Unit Pathol Anat, Vitoria, Alava, Spain
机构:
All India Inst Med Sci, Dept Pathol & Lab Med, Bibinagar, Hyderabad Metro, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bibinagar, Hyderabad Metro, India
Palo, Seetu
Mishra, Debadutta
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机构:
Andaman & Nicobar Isl Inst Med Sci, Dept Microbiol, Port Blair, Andaman & Nicob, IndiaAll India Inst Med Sci, Dept Pathol & Lab Med, Bibinagar, Hyderabad Metro, India