Preclinical determination of wound-healing activity of halibut oil cream in rat model of burn wound

被引：2
|
作者：
Shukla, S. T. [1 ]
Kaushik, Anu [1 ]
Auti, Samiullah Allahbaksh [2 ]
Kumar, Dinesh [1 ]
Das, Supriya Kumar [3 ]
机构：
[1] Shri JJT Univ, Pharmaceut Sci, Jhunjhunu, Rajasthan, India
[2] Rajiv Gandhi Inst Pharmaceut Sci & Res, Kasargod, Kerala, India
[3] Pretox Res Ctr, Surat, Gujarat, India
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2024年 / 26卷 / 12期
关键词：
Halibut oil; wound burn model; wound area contraction; acute dermal toxicity; inflammatory phase; proliferative phase; SUPEROXIDE DISMUTASE; REDUCED GLUTATHIONE; VITAMIN-A; OMEGA-3-FATTY-ACIDS; FISH; TOXICITY; HEALTH; MUSCLE; SKIN;
D O I：
10.1080/10286020.2024.2368835
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
This study investigated the effects of halibut oil cream, containing omega-3 fatty acids, vitamins A and D, and hydroxyproline, on burn wound healing in rats. Acute dermal toxicity tests confirmed its nontoxicity. Wistar rats were divided into five groups: a control, a positive control treated with silver sulfadiazine 1% (SSD), and three groups treated with 3%, 9%, and 27% halibut oil cream Formulation (HBOF). The SSD and HBOF groups showed significant healing improvements compared to the control. Histopathological analysis indicated increased collagen production in the HBOF groups, suggesting halibut oil cream's potential as a topical treatment for burn wounds. [GRAPHICS]
引用
收藏
页码：1455 / 1474
页数：20
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