Alterations of the Fatty Acid Profile and the Expression of Genes Related to FA Metabolism in Cirrhotic Liver Tissue

被引：0
|
作者：
Hliwa, Aleksandra [1 ]
Lange-Andrzejewska, Oliwia [2 ]
Laski, Dariusz [3 ]
Sledzinski, Maciej [3 ]
Remiszewski, Piotr [3 ]
Drobinska, Anna [4 ]
Mika, Adriana [1 ,2 ]
Sledzinski, Tomasz [1 ]
机构：
[1] Med Univ Gdansk, Fac Pharm, Dept Pharmaceut Biochem, Debinki 1, PL-80211 Gdansk, Poland
[2] Univ Gdansk, Fac Chem, Dept Environm Analyt, Wita Stwosza 63, PL-80308 Gdansk, Poland
[3] Med Univ Gdansk, Fac Med, Dept Gen Endocrine & Transplant Surg, Smoluchowskiego 17, PL-80214 Gdansk, Poland
[4] Med Univ Gdansk, Fac Med, Dept Paediat Nephrol & Hypertens, Smoluchowskiego 17, PL-80214 Gdansk, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 15期
关键词：
cirrhosis; fatty acids; ALD; NASH; NAFLD; lipids; RISK; PATHWAYS; FAILURE;
D O I：
10.3390/ijms25158115
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In addition to direct damage to hepatocytes, long-term ethanol consumption leads to lipid accumulation and hepatic steatosis, as well as to the dysregulation of lipid metabolism. The final step in various liver diseases is cirrhosis. The aim of this study was to compare the FA (fatty acids) profile and expression levels of genes involved in lipid metabolism in cirrhotic liver tissue and normal liver tissue. Exploring the changes in the FA profile and expression of genes related to fatty acid metabolism in cirrhotic liver tissue reveals a molecular landscape that goes beyond the surface of traditional liver function assessments. Understanding the shifts in gene expression and fatty acid composition in liver tissue opens avenues for interventions that may aid in the treatment of cirrhosis in the future.
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页数：14
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