Efficacy of Combination Therapies for Autoimmune Hepatitis: A Systematic Review and Meta-Analysis

被引：0
|
作者：
Rashad, Essam [1 ]
Moazam, Mustafa M. [2 ]
Chaudhry, Raheel [3 ]
El Eraky, Noha [4 ]
Mirza, Muhammad Sohail S. [5 ]
Nazmin, Farhana [6 ]
机构：
[1] Parkview Reg Med Ctr, Hosp Med, Ft Wayne, IN USA
[2] Texas Tech Univ, Psychiat, Hlth Sci Ctr El Paso, El Paso, TX USA
[3] Baylor Coll Med, Med, Houston, TX USA
[4] St Vincents Univ Hosp, Radiol, Dublin, Ireland
[5] Shandong Univ, Sch Med, Jinan, Peoples R China
[6] BronxCare Hlth Syst, Psychiat, Bronx, NY USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 05期
关键词：
azathioprine; prednisolone; efficacy; combination therapy; autoimmune hepatitis; AFFIRMATIVE-ACTION BANS; DIVERSITY; COLLEGE; SCIENCE; MATRICULATION; STUDENTS; SUCCESS; GENDER;
D O I：
10.7759/cureus.60049
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autoimmune hepatitis (AIH) is a hepatocellular disorder thought to be caused by an immune system that cannot tolerate autoantigens specific to hepatocytes. This study aims to evaluate the efficacy of using corticosteroids (prednisolone and azathioprine) as a combination therapy in treating AIH. This study aims to synthesize and analyze existing evidence to inform clinical practices concerning the overall clinical efficacy of this treatment approach in managing AIH. A comprehensive search was conducted across multiple online databases and search engines, including PubMed, Google Scholar, ScienceDirect, Medline, and Embase. RevMan 5.4 software was used for metaanalysis, with forest plots created for each outcome. Thirteen studies were included in this systematic review and meta -analysis. The results indicate that the combination of prednisolone and azathioprine for treating AIH leads to less recurrence and better disease control.
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页数：10
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