Lung function trajectories in South African children with pulmonary tuberculosis compared to those with non-TB lower respiratory tract infection: a prospective study

被引:1
|
作者
Gray, Diane M. [1 ,2 ]
Githinji, Leah [1 ,2 ]
Brittain, Kirsty [1 ,2 ]
Franckling-Smith, Zoe [1 ,2 ]
Bateman, Lindy [1 ,2 ]
Prins, Margaretha [1 ,2 ]
Baard, Cynthia B. [1 ,2 ]
McFarlane, David [1 ,2 ]
Nicol, Mark P. [3 ]
Workman, Lesley [1 ,2 ]
Zar, Heather J. [1 ,2 ]
机构
[1] Univ Cape Town, Dept Paediat & Child Hlth, Red Cross War Mem Childrens Hosp, Cape Town, South Africa
[2] Univ Cape Town, SA MRC Unit Child & Adolescent Hlth, Cape Town, South Africa
[3] Univ Western Australia, Marshall Ctr Infect & Immun, Sch Biomed Sci, Perth, Australia
基金
英国医学研究理事会; 美国国家卫生研究院;
关键词
SPIROMETRY;
D O I
10.1183/13993003.00216-2024
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Paediatric pulmonary tuberculosis (PTB) contributes substantially to child illness globally [1]. Advances in diagnosis and treatment have improved survival [2], but the long-term impact is a concern [3, 4]. Childhood PTB has been associated with chronic radiological changes, respiratory symptoms and reduced lung function, with impaired lung volumes common after TB treatment completion [5–7]. However, whether such impairment is similar with PTB compared to those with non-TB lower respiratory tract infection (LRTI) from the time of LRTI diagnosis until 3 months is unknown. We aimed to investigate the impact on lung health by longitudinally measuring lung function in children with PTB compared to those with non-TB LRTI from the time of TB diagnosis until 3 months in all and extended follow-up in children with PTB until 6 months after treatment completion. ©The authors 2024.
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页数:4
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