Soluble epoxide hydrolase: an emerging target for nutraceuticals against inflammation and oxidative stress

Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxy fatty acids into diols. Epoxy fatty acids are signaling molecules that are involved in inflammation, regulation of the redox state, blood pressure, and pain perception, among other physiological functions. Downregulation of sEH activity in various cells has been used for the treatment and management of various cardiovascular and neurodegenerative diseases. Thus, sEH inhibition is an emerging target against inflammation, oxidative stress, and their associated diseases. This paper discusses recent advances and future perspectives in sEH inhibition by extracts and compounds from food sources, including polyphenols, protein hydrolysates and peptides, protoalkaloids, triterpenoids, and fatty acids.