The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update

被引:8
|
作者
Rakotoarivelo, Volatiana [1 ,2 ]
Mayer, Thomas Z. [1 ,2 ,3 ,4 ]
Simard, Melissa [1 ,2 ]
Flamand, Nicolas [1 ,2 ]
Di Marzo, Vincenzo [1 ,2 ,3 ,4 ,5 ]
机构
[1] Univ Laval, Ctr Rech Inst, Dept Med, Univ Cardiol & Pneumol Quebec, Quebec City, PQ G1V 4G5, Canada
[2] Univ Laval, Canada Excellence Res Chair Microbiome Endocannabi, Quebec City, PQ G1V 0V6, Canada
[3] Univ Laval, Ecole Nutr, Inst Nutr & Aliments Fonct, Quebec City, PQ G1V 0V6, Canada
[4] Univ Laval, Ecole Nutr, Ctr NUTRISS, Quebec City, PQ G1V 0V6, Canada
[5] Joint Int Unit CNR Italy & Univ Laval, Chem & Biomol Res Microbiome & Its Impact Metab H, Quebec City, PQ G1V 0V6, Canada
来源
MOLECULES | 2024年 / 29卷 / 14期
基金
加拿大健康研究院;
关键词
inflammatory diseases; inflammation; cannabinoid; endocannabinoid; cannabinoid receptor; ACID AMIDE HYDROLASE; ENDOGENOUS LIGAND 2-ARACHIDONOYLGLYCEROL; MONOGLYCERIDE LIPASE DEFICIENCY; INNATE LYMPHOID-CELLS; FATTY LIVER-DISEASE; TYPE-2; RECEPTOR; MURINE MODEL; ENDOCANNABINOID SYSTEM; EXPERIMENTAL COLITIS; NOLADIN ETHER;
D O I
10.3390/molecules29143381
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia to treat inflammatory disorders such as rheumatism or gout. Since the characterization of cannabinoid receptors, CB1 and CB2, the potential of cannabinoid pharmacotherapy in inflammatory conditions has received great interest. Several studies have identified the importance of these receptors in immune cell migration and in the production of inflammatory mediators. As the presence of the CB2 receptor was documented to be more predominant in immune cells, several pharmacological agonists and antagonists have been designed to treat inflammation. To better define the potential of the CB2 receptor, three online databases, PubMed, Google Scholar and clinicaltrial.gov, were searched without language restriction. The full texts of articles presenting data on the endocannabinoid system, the CB2 receptor and its role in modulating inflammation in vitro, in animal models and in the context of clinical trials were reviewed. Finally, we discuss the clinical potential of the latest cannabinoid-based therapies in inflammatory diseases.
引用
收藏
页数:36
相关论文
共 50 条
  • [41] Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**
    Morales, Paula
    Navarro, Gemma
    Gomez-Autet, Marc
    Redondo, Laura
    Fernandez-Ruiz, Javier
    Perez-Benito, Laura
    Cordomi, Arnau
    Pardo, Leonardo
    Franco, Rafael
    Jagerovic, Nadine
    CHEMISTRY-A EUROPEAN JOURNAL, 2020, 26 (68) : 15839 - 15842
  • [42] Structural basis of selective cannabinoid CB2 receptor activation
    Xiaoting Li
    Hao Chang
    Jara Bouma
    Laura V. de Paus
    Partha Mukhopadhyay
    Janos Paloczi
    Mohammed Mustafa
    Cas van der Horst
    Sanjay Sunil Kumar
    Lijie Wu
    Yanan Yu
    Richard J. B. H. N. van den Berg
    Antonius P. A. Janssen
    Aron Lichtman
    Zhi-Jie Liu
    Pal Pacher
    Mario van der Stelt
    Laura H. Heitman
    Tian Hua
    Nature Communications, 14
  • [43] ROLE OF CANNABINOID CB2 RECEPTOR IN THE REINFORCING ACTIONS OF ETHANOL
    Garcia-Gutierrez, M. S.
    Navarrete, F.
    Aracil-Fernandez, A.
    Ortega-Alvaro, A.
    Ternianov, A.
    Manzanares, J.
    ALCOHOL AND ALCOHOLISM, 2015, 50
  • [44] Knockout controls and the specificity of cannabinoid CB2 receptor antibodies
    Ashton, John C.
    BRITISH JOURNAL OF PHARMACOLOGY, 2011, 163 (06) : 1113 - 1113
  • [45] Structural basis of selective cannabinoid CB2 receptor activation
    Li, Xiaoting
    Chang, Hao
    Bouma, Jara
    de Paus, Laura V.
    Mukhopadhyay, Partha
    Paloczi, Janos
    Mustafa, Mohammed
    van der Horst, Cas
    Kumar, Sanjay Sunil
    Wu, Lijie
    Yu, Yanan
    van den Berg, Richard J. B. H. N.
    Janssen, Antonius P. A.
    Lichtman, Aron
    Liu, Zhi-Jie
    Pacher, Pal
    van der Stelt, Mario
    Heitman, Laura H.
    Hua, Tian
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [46] Role of cannabinoid CB2 receptor in Parkinson's disease
    Navarrete Rueda, F.
    Garcia-Gutierrez, M. S.
    Aracil-Fernandez, A.
    Molina-Arjona, J. A.
    Leiva-Santana, C.
    Manzanares, J.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2014, 24 : S646 - S647
  • [47] Cloning and pharmacological characterization of the rat CB2 cannabinoid receptor
    Griffin, G
    Tao, Q
    Abood, ME
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2000, 292 (03): : 886 - 894
  • [48] CB2 cannabinoid receptor-mediated peripheral antinociception
    Malan, TP
    Ibrahim, MM
    Deng, HF
    Liu, Q
    Mata, HP
    Vanderah, T
    Porreca, F
    Makriyannis, A
    PAIN, 2001, 93 (03) : 239 - 245
  • [49] CB1 and CB2 cannabinoid receptors are implicated in inflammatory hypersensitivity to pain
    Clayton, NM
    O'Shaughnessy, CT
    Marshall, F
    Bountra, C
    BRITISH JOURNAL OF PHARMACOLOGY, 2001, 134
  • [50] Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
    Jared Ehrhart
    Demian Obregon
    Takashi Mori
    Huayan Hou
    Nan Sun
    Yun Bai
    Thomas Klein
    Francisco Fernandez
    Jun Tan
    R Douglas Shytle
    Journal of Neuroinflammation, 2