Afatinib-induced toxic epidermal necrolysis: A case report with a literature review

被引：0

作者：

Belancic, Andrej ^{[1
,2
]}

Hlaca, Nika ^{[3
,4
]}

Peternel, Sandra ^{[3
,4
]}

Golcic, Marin ^{[5
]}

Prpic-Massari, Larisa ^{[3
,4
]}

Vlahovic-Palcevski, Vera ^{[1
,2
]}

机构：

[1] Clin Hosp Ctr Rijeka, Dept Clin Pharmacol, Rijeka, Croatia

[2] Univ Rijeka, Fac Med, Dept Basic & Clin Pharmacol & Toxicol, Rijeka, Croatia

[3] Clin Hosp Ctr Rijeka, Dept Dermatovenerol, Kresimirova 42, Rijeka 5100, Croatia

[4] Univ Rijeka, Fac Med, Dept Dermatovenerol, Rijeka, Croatia

[5] Clin Hosp Ctr Rijeka, Dept Radiotherapy & Oncol, Rijeka, Croatia

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2024年 / 90卷 / 08期

关键词：

afatinib; pharmacovigilance; serious adverse drug reaction; toxic epidermal necrolysis; STEVENS-JOHNSON SYNDROME; LUNG ADENOCARCINOMA;

D O I：

10.1111/bcp.16114

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We present a 70-year-old female patient diagnosed with epidermal growth factor receptor-mutated metastatic non-small cell lung cancer (T4N2M1a), who developed afatinib-induced toxic epidermal necrolysis (TEN). We have also performed a PubMed/Medline literature review to detect other possible cases of TEN/Stevens-Johnson syndrome associated with afatinib treatment and found only 5 other cases reported. To our best knowledge, this is the first case of afatinib-induced TEN successfully treated with cyclosporine.

引用

页码：2030 / 2033

页数：4

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