Afatinib-induced toxic epidermal necrolysis: A case report with a literature review

被引：0
|
作者：
Belancic, Andrej [1 ,2 ]
Hlaca, Nika [3 ,4 ]
Peternel, Sandra [3 ,4 ]
Golcic, Marin [5 ]
Prpic-Massari, Larisa [3 ,4 ]
Vlahovic-Palcevski, Vera [1 ,2 ]
机构：
[1] Clin Hosp Ctr Rijeka, Dept Clin Pharmacol, Rijeka, Croatia
[2] Univ Rijeka, Fac Med, Dept Basic & Clin Pharmacol & Toxicol, Rijeka, Croatia
[3] Clin Hosp Ctr Rijeka, Dept Dermatovenerol, Kresimirova 42, Rijeka 5100, Croatia
[4] Univ Rijeka, Fac Med, Dept Dermatovenerol, Rijeka, Croatia
[5] Clin Hosp Ctr Rijeka, Dept Radiotherapy & Oncol, Rijeka, Croatia
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2024年 / 90卷 / 08期
关键词：
afatinib; pharmacovigilance; serious adverse drug reaction; toxic epidermal necrolysis; STEVENS-JOHNSON SYNDROME; LUNG ADENOCARCINOMA;
D O I：
10.1111/bcp.16114
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We present a 70-year-old female patient diagnosed with epidermal growth factor receptor-mutated metastatic non-small cell lung cancer (T4N2M1a), who developed afatinib-induced toxic epidermal necrolysis (TEN). We have also performed a PubMed/Medline literature review to detect other possible cases of TEN/Stevens-Johnson syndrome associated with afatinib treatment and found only 5 other cases reported. To our best knowledge, this is the first case of afatinib-induced TEN successfully treated with cyclosporine.
引用
收藏
页码：2030 / 2033
页数：4
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