Biochemical control in intermediate- and high-risk prostate cancer after EBRT with and without brachytherapy boost

Purpose External beam radiotherapy (EBRT) with or without brachytherapy boost (BTB) has not been compared in prospective studies using guideline-recommended radiation dose and recommended androgen-deprivation therapy (ADT). In this multicenter retrospective analysis, we compared modern-day EBRT with BTB in terms of biochemical control (BC) for intermediate-risk (IR) and high-risk (HR) prostate cancer.Methods Patients were treated for primary IR or HR prostate cancer during 1999-2019 at three high-volume centers. Inclusion criteria were prescribed >= 76 Gy EQD2 (alpha/beta = 1.5 Gy) for IR and >= 78 Gy EQD2 (alpha/beta = 1.5 Gy) for HR as EBRT alone or with BTB. All HR patients received ADT and pelvic irradiation, which were optional in IR cases. BC between therapies was compared in survival analyses.Results Of 2769 initial patients, 1176 met inclusion criteria: 468 HR (260 EBRT, 208 BTB) and 708 IR (539 EBRT, 169 BTB). Median follow-up was 49 and 51 months for HR and IR, respectively. BTB patients with >= 113 Gy EQD2Gy experienced a stable, good BC outcome compared with BTB at lower doses. Patients treated with >= 113 Gy EQD2Gy also experienced significantly improved BC compared with EBRT (10-year BC failure rates after >= 113 Gy BTB and EBRT: respectively 20.4 and 41.8% for HR and 7.5 and 20.8% for IR).Conclusions In patients with IR and HR prostate cancer, BTB with >= 113 Gy EQD2Gy offered a BC advantage compared with dose-escalated EBRT and lower BTB doses.