Ni-Catalyzed Reductive 1,2-Alkylarylation of Alkenes for the Synthesis of Spirocyclic γ-Lactams

被引：2

作者：

Pearson, James W. ^{[1
]}

Hou, Teh Ren ^{[1
]}

Golijanin, Jelena ^{[1
]}

Stewart, Patricia I. ^{[1
]}

Choi, Eun Seo ^{[1
]}

Gabbey, Alexis L. ^{[1
]}

West, Michael S. ^{[1
]}

Rousseaux, Sophie A. L. ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 26期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

REDOX-ACTIVE ESTERS; DICARBOFUNCTIONALIZATION; STRATEGY; OLEFINS;

D O I：

10.1021/acs.orglett.4c01981

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intermolecular nickel-catalyzed reductive 1,2-alkylarylation of acrylates with cyclopropylamine NHP esters and aryl iodides is reported. This operationally simple protocol provides direct access to 1-alkylcyclopropylamine scaffolds. The mild conditions are compatible with four-membered alpha-amino strained rings as well as five- and six-membered ring systems. The products undergo cyclization to access alpha-arylated spirocyclic gamma-lactams-a motif present in several pharmaceuticals.

引用

页码：5560 / 5565

页数：6

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