Stem Cell-Based Approaches in Parkinson's Disease Research

被引：3

作者：

Kim, Min Seong ^{[1
,2
,9
]}

Yoon, Subeen ^{[3
]}

Choi, Jiwoo ^{[3
]}

Kim, Yong Jun ^{[3
,4
,5
,8
]}

Lee, Gabsang ^{[1
,2
,6
,7
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, 733 N Broadway, Baltimore, MD 21218 USA

[3] Kyung Hee Univ, Grad Sch, Dept Biomed Sci, 26 Kyungheedae-ro,Dongdaemun-gu, Seoul 02447, South Korea

[4] Kyung Hee Univ, Coll Med, Dept Pathol, Seoul, South Korea

[5] Kyung Hee Univ, Grad Sch, KHU KIST Dept Converging Sci & Technol, Seoul, South Korea

[6] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD USA

[7] Johns Hopkins Univ, Sch Med, Dept Neurol, 733 N Broadway, Baltimore, MD 21205 USA

[8] Kyung Hee Univ, Coll Med, Dept Pathol, 26 Kyungheedae, Seoul 02447, South Korea

[9] Sejong Univ, Dept Integrat Biosci & Biotechnol, Seoul, South Korea

来源：

INTERNATIONAL JOURNAL OF STEM CELLS | 2024年

基金：

新加坡国家研究基金会;

关键词：

Disease model; Parkinson disease; Stem cell therapy; Pathological mechanism; MIDBRAIN DOPAMINERGIC-NEURONS; PATHOLOGICAL ALPHA-SYNUCLEIN; MITOCHONDRIAL DYSFUNCTION; NEURAL STEM; FAMILIAL DYSAUTONOMIA; PROGENITOR CELLS; LYSOSOMAL DYSFUNCTION; BRAIN ORGANOIDS; IN-VIVO; LRRK2;

D O I：

10.15283/ijsc23169

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of midbrain dopaminergic neurons, leading to motor symptoms. While current treatments provide limited relief, they don't alter disease progression. Stem cell technology, involving patient-specific stem cell-derived neurons, offers a promising avenue for research and personalized regenerative therapies. This article reviews the potential of stem cell -based research in PD, summarizing ongoing efforts, their limitations, and introducing innovative research models. The integration of stem cell technology and advanced models promises to enhance our understanding and treatment strategies for PD.

引用

页数：16

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