Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China

被引：0

作者：

Yao, Hui ^{[1
]}

Shen, Ying ^{[1
]}

Liang, Zhichao ^{[2
]}

Xue, Xiaoyu ^{[3
]}

Zhao, Chenxi ^{[3
]}

Xu, Xiang ^{[1
]}

Cai, Yuxin ^{[1
]}

Liu, Yonghong ^{[1
]}

Zhang, Wei ^{[3
]}

Pan, Yang ^{[4
]}

Wang, Xiaoli ^{[1
,5
,6
]}

机构：

[1] Beijing Ctr Dis Prevent & Control, Beijing Off Global Hlth, Beijing 100013, Peoples R China

[2] Beijing Ctr Dis Prevent & Control, Inst Infect Dis & Endem Dis Control, Beijing 100013, Peoples R China

[3] Capital Med Univ, Beijing Ditan Hosp, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing 100015, Peoples R China

[4] Natl Med Prod Adm, Ctr Drug Evaluat, Beijing 100176, Peoples R China

[5] Capital Med Univ, Sch Publ Hlth, Beijing 100069, Peoples R China

[6] Beijing Ctr Dis Prevent & Control, Beijing 100013, Peoples R China

来源：

BIOSAFETY AND HEALTH | 2024年 / 6卷 / 02期

关键词：

SARS-CoV-2; Saliva sample; Sensitivity; Acceptability;

D O I：

10.1016/j.bsheal.2024.03.002

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In response to problems of poor sampling quality, low sensitivity, and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) oropharyngeal (OP) swab sampling used in China, we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests (NAATs) in China. The results showed that, using nasopharyngeal (NP) swab results as the gold standard, the overall sensitivities for saliva specimens and OP swabs were 93.3 % and 85.0 %, the specificities were 92.6 % and 93.8 %, respectively. The results of an acceptability survey showed that the scores for saliva, OP, and NP samples were 9.46 +/- 1.69, 8.11 +/- 2.42, and 4.58 +/- 3.82 out of 10, respectively, with significant differences among the three groups (P < 0.05). With higher sensitivity, comparable specificity, and strong public preference, saliva-based NAATs represent a convenient and effective method for detecting SARS-CoV-2 in future epidemics. (c) 2024 Chinese Medical Association Publishing House. Published by Elsevier BV This is an open access article

引用

页码：88 / 91

页数：4

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