Bakuchiol impact on ageing and longevity: Insights from Caenorhabditis elegans studies

The efficacy of any herbal medication hinges on delivering adequate levels of plant extract from the therapeutically active phytomolecules. Bakuchiol (BAK), a monoterpenoid derived from Psoralea corylifolia with its relevance in cultural and traditional Chinese medicine. Owing to its unique aspects, this molecule has been demonstrated to improve lifespan and antiageing with fewer side effects than synthetic alternatives and easier to use. BAK offers enormous benefits for skin rejuvenation; it acts as a natural retinol alternative, enhancing collagen formation, maintaining skin suppleness and minimizing wrinkles. Furthermore, research conducted on the model organism Caenorhabditis elegans, a nematode and prominently one of the primo model systems for ageing research has revealed significant elevation of acetylcholine (Ach) transmission, reduction in reactive oxygen species (ROS) levels and extension of lifespan. Research into the longevity of this model organism using phytomolecules is an intriguing area that explores the potential of leverageing natural compounds derived from plants to prolong the lifespan of this model organism. C. elegans has provided valuable insights into the intricate molecular and genetic mechanisms underlying the ageing process. The emerging complex relationship between bakuchiol and C. elegans revealed the mechanisms controlling development and lifespan by gently altering longevity genes, particularly those within the mTOR and insulin/IGF-1 signaling pathways, BAK bestowed worms the ability of extended lifespan by promoting cellular renewal. The current study sheds light on its potential to alter cellular pathways linked to longevity and suggest its ability to activate proteins strongly associated with extended lifespans and better health.