SERINE/GLYCINE METABOLISM REPRESENTS A NOVEL TARGETABLE THERAPEUTIC VULNERABILITY IN MYC-AMPLIFIED MEDULLOBLASTOMA

被引：0
|
作者：
Adiamah, Magretta [1 ,2 ]
Poole, Bethany [1 ]
Lindsey, Janet C. [1 ]
Swartz, Shanel [1 ]
Morcavallo, Alaide [3 ,4 ]
Gosling, Samantha Jepson [1 ]
Singh, Mankaran [1 ]
Blair, Helen J. [1 ]
Kohe, Sarah [5 ]
Zhang, Tong [6 ]
Maddocks, Oliver [6 ]
Peet, Andrew [5 ]
Chesler, Louis [3 ,4 ]
Hickson, Ian [1 ]
Maxwell, Ross [1 ]
Hill, Rebecca M. [1 ]
Clifford, Steven C. [1 ]
机构：
[1] Newcastle Univ, Ctr Canc, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England
[2] Luxembourg Inst Hlth, Dept Canc Res, Luxembourg, Luxembourg
[3] Inst Canc Res ICR, Div Clin Studies, London, England
[4] Royal Marsden NHS Trust, Sutton, Surrey, England
[5] Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England
[6] Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland
来源：
NEURO-ONCOLOGY | 2024年 / 26卷
关键词：
D O I：
10.1093/neuonc/noae064.523
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MDB-74
引用
收藏
页数：1
相关论文
共 50 条
  • [21] OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma
    Xu, Zhenhua
    Murad, Najiba
    Malawsky, Daniel
    Tao, Ran
    Rivero-Hinojosa, Samuel
    Holdhof, Doerthe
    Schueller, Ulrich
    Zhang, Peng
    Lazarski, Christopher
    Rood, Brian R.
    Packer, Roger
    Gershon, Timothy
    Pei, Yanxin
    CLINICAL CANCER RESEARCH, 2022, 28 (19) : 4278 - 4291
  • [22] HDACs and MYC in medulloblastoma: how do HDAC inhibitors control MYC-amplified tumors?
    Shofuda, Tomoko
    Kanemura, Yonehiro
    NEURO-ONCOLOGY, 2021, 23 (02) : 173 - 174
  • [23] RESISTANCE MECHANISMS TO BET-BROMODOMAIN INHIBITION IN MYC-AMPLIFIED MEDULLOBLASTOMA
    Bandopadhayay, Pratiti
    Paolella, Brenton
    O'Rourke, Ryan
    Ho, Patricia
    Greenwald, Noah
    Sharpira, Ofer
    Pantel, Sasha
    Bagul, Mukta
    Tracy, Adam
    Roti, Giovanni
    Balboni, Amanda
    Vazquez, Francisca
    Ligon, Keith
    Piccioni, Federica
    Stegmaier, Kimberly
    Johannessen, Cory
    Beroukhim, Rameen
    NEURO-ONCOLOGY, 2017, 19 : 54 - 55
  • [24] Exploring integrated stress response pathway to target MYC-amplified medulloblastoma
    Langman, Sofya
    Sorensen, Poul H.
    CANCER RESEARCH, 2020, 80 (16)
  • [25] Polymeric nanomedicine for overcoming resistance mechanisms in hedgehog and Myc-amplified medulloblastoma
    Kumar, Virender
    Wang, Qiyue
    Sethi, Bharti
    Lin, Feng
    Kumar, Vinod
    Coulter, Donald W.
    Dong, Yuxiang
    Mahato, Ram, I
    BIOMATERIALS, 2021, 278
  • [26] Polymeric nanomedicine for overcoming resistance mechanisms in hedgehog and Myc-amplified medulloblastoma
    Kumar, Virender
    Wang, Qiyue
    Sethi, Bharti
    Lin, Feng
    Kumar, Vinod
    Coulter, Donald W.
    Dong, Yuxiang
    Mahato, Ram I.
    Biomaterials, 2021, 278
  • [27] WNT-activated, MYC-amplified medulloblastoma displaying intratumoural heterogeneity
    Green, Sage
    Hoover, Travis
    Doss, David
    Davidow, Kimberly
    Walter, Andrew W.
    Cottrell, Catherine E.
    Mahapatra, Sidharth
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2024, 50 (01)
  • [28] α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth
    Soma Sengupta
    Shyamal Dilhan Weeraratne
    Hongyu Sun
    Jillian Phallen
    Sundari K. Rallapalli
    Natalia Teider
    Bela Kosaras
    Vladimir Amani
    Jessica Pierre-Francois
    Yujie Tang
    Brian Nguyen
    Furong Yu
    Simone Schubert
    Brianna Balansay
    Dimitris Mathios
    Mirna Lechpammer
    Tenley C. Archer
    Phuoc Tran
    Richard J. Reimer
    James M. Cook
    Michael Lim
    Frances E. Jensen
    Scott L. Pomeroy
    Yoon-Jae Cho
    Acta Neuropathologica, 2014, 127 : 593 - 603
  • [29] α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth
    Sengupta, Soma
    Weeraratne, Shyamal Dilhan
    Sun, Hongyu
    Phallen, Jillian
    Rallapalli, Sundari K.
    Teider, Natalia
    Kosaras, Bela
    Amani, Vladimir
    Pierre-Francois, Jessica
    Tang, Yujie
    Brian Nguyen
    Yu, Furong
    Schubert, Simone
    Balansay, Brianna
    Mathios, Dimitris
    Lechpammer, Mirna
    Archer, Tenley C.
    Phuoc Tran
    Reimer, Richard J.
    Cook, James M.
    Lim, Michael
    Jensen, Frances E.
    Pomeroy, Scott L.
    Cho, Yoon-Jae
    ACTA NEUROPATHOLOGICA, 2014, 127 (04) : 593 - 603
  • [30] HDACi AND PLIK1I ACT SYNERGISTICALLY IN MYC-AMPLIFIED MEDULLOBLASTOMA
    Valinciute, Gintvile
    Ecker, Jonas
    Hielscher, Thomas
    Schmidt, Christin
    Remke, Marc
    Sigismondo, Gianluca
    Krijgsveld, Jeroen
    Pfister, Stefan
    Witt, Olaf
    Milde, Till
    NEURO-ONCOLOGY, 2019, 21 : 103 - 103
12345