SERINE/GLYCINE METABOLISM REPRESENTS A NOVEL TARGETABLE THERAPEUTIC VULNERABILITY IN MYC-AMPLIFIED MEDULLOBLASTOMA

被引:0
|
作者
Adiamah, Magretta [1 ,2 ]
Poole, Bethany [1 ]
Lindsey, Janet C. [1 ]
Swartz, Shanel [1 ]
Morcavallo, Alaide [3 ,4 ]
Gosling, Samantha Jepson [1 ]
Singh, Mankaran [1 ]
Blair, Helen J. [1 ]
Kohe, Sarah [5 ]
Zhang, Tong [6 ]
Maddocks, Oliver [6 ]
Peet, Andrew [5 ]
Chesler, Louis [3 ,4 ]
Hickson, Ian [1 ]
Maxwell, Ross [1 ]
Hill, Rebecca M. [1 ]
Clifford, Steven C. [1 ]
机构
[1] Newcastle Univ, Ctr Canc, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England
[2] Luxembourg Inst Hlth, Dept Canc Res, Luxembourg, Luxembourg
[3] Inst Canc Res ICR, Div Clin Studies, London, England
[4] Royal Marsden NHS Trust, Sutton, Surrey, England
[5] Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England
[6] Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland
关键词
D O I
10.1093/neuonc/noae064.523
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
MDB-74
引用
收藏
页数:1
相关论文
共 50 条
  • [1] MYC-DRIVEN UPREGULATION OF THE DE NOVO SERINE AND GLYCINE PATHWAY IS A NOVEL THERAPEUTIC TARGET FOR GROUP 3 MYC-AMPLIFIED MEDULLOBLASTOMA
    Adiamah, Magretta
    Lindsey, Janet C.
    Burte, Florence
    Kohe, Sarah
    Morcavallo, Alaide
    Blair, Helen
    Hill, Rebecca M.
    Singh, Mankaran
    Crosier, Stephen
    Zhang, Tong
    Maddocks, Oliver
    Peet, Andrew
    Chesler, Louis
    Hickson, Ian
    Maxwell, Ross
    Clifford, Steven C.
    NEURO-ONCOLOGY, 2022, 24 : 125 - 125
  • [2] LIPID SATURATION HOMEOSTASIS PRESENTS A TARGETABLE VULNERABILITY IN MYC-AMPLIFIED GROUP 3 MEDULLOBLASTOMA
    Custers, Stefan
    NEURO-ONCOLOGY, 2024, 26
  • [3] OLIG2 REPRESENTS A PROGNOSTIC MARKER AND THERAPEUTIC TARGET IN MYC-AMPLIFIED MEDULLOBLASTOMA RELAPSE AND METASTASIS
    Xu, Zhenhua
    Murad, Najiba
    Rivero-Hinojosa, Samuel
    Schueller, Ulrich
    Zhang, Peng
    Liu, Xiao
    Rood, Brian
    Packer, Roger
    Pei, Yanxin
    NEURO-ONCOLOGY, 2021, 23 : 5 - 6
  • [4] PRMT5 as a Potential Therapeutic Target in MYC-Amplified Medulloblastoma
    Kumar, Devendra
    Jain, Stuti
    Coulter, Don W.
    Joshi, Shantaram S.
    Chaturvedi, Nagendra K.
    CANCERS, 2023, 15 (24)
  • [5] DISTRIBUTION AND VULNERABILITY OF TRANSCRIPTIONAL OUTPUTS ACROSS THE GENOME IN MYC-AMPLIFIED MEDULLOBLASTOMA CELLS
    Yang, Rui
    Wang, Wenzhe
    Dong, Meichen
    Roso, Kristen
    Bao, Xuhui
    Pirozzi, Christopher
    Bigner, Darell
    Yan, Hai
    Ashley, David
    Zhabotynsky, Vasyl
    Zou, Fei
    He, Yiping
    NEURO-ONCOLOGY, 2021, 23 : 5 - 5
  • [6] INNATE IMMUNE EVASION IN MYC-AMPLIFIED MEDULLOBLASTOMA
    Vo, Jeremy
    Mitra, Juni S.
    Knox, Aaron
    Picard, Daniel
    Vibhakar, Rajeev
    Hankinson, Todd
    Mitra, Siddhartha S.
    NEURO-ONCOLOGY, 2024, 26
  • [7] BET BROMODOMAIN INHIBITION OF MYC-AMPLIFIED MEDULLOBLASTOMA
    Bandopadhayay, P.
    Nguyen, B.
    Masoud, S.
    Vue, N.
    Gholamin, S.
    Yu, F.
    Schubert, S.
    Bergthold, G.
    Mitra, S.
    Cheshire, S.
    Qi, J.
    Bradner, J. E.
    Kieran, M. W.
    Beroukhim, R.
    Cho, Y. J.
    PEDIATRIC BLOOD & CANCER, 2013, 60 : 36 - 36
  • [8] BET BROMODOMAIN INHIBITION OF MYC-AMPLIFIED MEDULLOBLASTOMA
    Bandopadhayay, Pratiti
    Nguyen, Brian
    Masoud, Sabran
    Vue, Nujsaubnusi
    Gholamin, Sharareh
    Yu, Furong
    Schubert, Simone
    Bergthold, Guillaume
    Mitra, Siddhartha
    Qi, Jun
    Bradner, James
    Kieran, Mark
    Beroukhim, Rameen
    Cho, Yoon-Jae
    NEURO-ONCOLOGY, 2013, 15 : 36 - 36
  • [9] BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
    Bandopadhayay, Pratiti
    Bergthold, Guillaume
    Nguyen, Brian
    Schubert, Simone
    Gholamin, Sharareh
    Tang, Yujie
    Bolin, Sara
    Schumacher, Steven E.
    Zeid, Rhamy
    Masoud, Sabran
    Yu, Furong
    Vue, Nujsaubnusi
    Gibson, William J.
    Paolella, Brenton R.
    Mitra, Siddhartha S.
    Cheshier, Samuel H.
    Qi, Jun
    Liu, Kun-Wei
    Wechsler-Reya, Robert
    Weiss, William A.
    Swartling, Fredrik J.
    Kieran, Mark W.
    Bradner, James E.
    Beroukhim, Rameen
    Cho, Yoon-Jae
    CLINICAL CANCER RESEARCH, 2014, 20 (04) : 912 - 925
  • [10] TARGETING CTPS1 AND NUCLEOTIDE BIOSYNTHESIS PATHWAYS AS A NOVEL THERAPEUTIC APPROACH IN MYC-AMPLIFIED MEDULLOBLASTOMA
    Hathaway, Matthew
    Jagana, Hawa
    Terrones, Isabella
    Miyaki, Aya
    Hemenway, John
    Meechan, Michael
    Gadek, Kate
    Slusher, Barbara
    Evans II, Myron
    NEURO-ONCOLOGY, 2024, 26