IgE to cyclophilins in pollen-allergic children: Epidemiologic, clinical, and diagnostic relevance of a neglected panallergen

被引：3

作者：

Matricardi, Paolo Maria ^{[1
,2
,3
,4
,5
]}

Potapova, Ekaterina ^{[1
,2
,3
]}

Panetta, Valentina ^{[6
]}

Lidholm, Jonas ^{[7
]}

Mattsson, Lars ^{[7
]}

Scala, Enrico ^{[8
]}

Bernardini, Roberto ^{[9
]}

Caffarelli, Carlo ^{[10
]}

Casani, Antonella ^{[11
]}

Cervone, Rosa ^{[9
]}

Chini, Loredana ^{[12
]}

Comberiati, Pasquale ^{[13
]}

De Castro, Giovanna ^{[14
]}

del Giudice, Michele Miraglia ^{[15
]}

Dello Iacono, Iride ^{[16
]}

Businco, Andrea Di Rienzo ^{[17
,18
]}

Gallucci, Marcella ^{[19
]}

Giannetti, Arianna ^{[20
]}

Moschese, Viviana ^{[12
]}

Varin, Elena ^{[21
]}

Bianchi, Annamaria ^{[22
]}

Calvani, Mauro ^{[22
]}

Frediani, Tullio ^{[14
]}

Macri, Francesco ^{[14
]}

Maiello, Nunzia ^{[15
]}

Paravati, Francesco ^{[23
]}

Pelosi, Umberto ^{[24
]}

Peroni, Diego ^{[25
]}

Pingitore, Giuseppe ^{[26
]}

Tosca, Mariangela ^{[27
]}

Zicari, Anna Maria ^{[14
]}

Ricci, Giampaolo ^{[19
]}

Asero, Riccardo ^{[28
]}

Tripodi, Salvatore ^{[17
,18
]}

机构：

[1] Charite Univ Med Berlin, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Dept Pediat Resp Med Immunol & Crit Care Med, Berlin, Germany

[4] Charite Univ Med Berlin, Inst Allergol, Berlin, Germany

[5] Fraunhofer Inst Translat Med & Pharmacol ITMP, Dept Allergol & Immunol, Berlin, Germany

[6] Altrastatistica, Consultancy & Training Biostat, Rome, Italy

[7] Thermo Fisher Sci, Uppsala, Sweden

[8] IDI IRCCS, Clin & Lab Mol AllergyUnit, Rome, Italy

[9] San Giuseppe Hosp, Pediat Unit, Empoli, Italy

[10] Univ Parma, Dept Med & Surg, Clin Pediat, Parma, Italy

[11] Pediat Libera Scelta, Benevento, Italy

[12] Univ Roma Tor Vergata, Policlin Tor Vergata, UOSD Immunopatol Allergol Pediat, Rome, Italy

[13] Univ Pisa, Dept Clin & Expt Med, Sect Paediat, Pisa, Italy

[14] Univ Roma La Sapienza, Pediat Dept, Rome, Italy

[15] Univ Campania Luigi Vanvitelli, Dipartimento Donna Bambino & Chirurg Gen & Special, Naples, Italy

[16] Fatebenefratelli Hosp, Pediat Unit, Benevento, Italy

[17] Sandro Pertini Hosp, Pediat Dept, Rome, Italy

[18] Sandro Pertini Hosp, Pediat Allergol Unit, Rome, Italy

[19] IRCCS Azienda Osped Univ Bologna, Pediat Unit, Bologna, Italy

[20] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Intermediate Care Unit, Milan, Italy

[21] San Carlo Clin, Allergol Serv, Milan, Italy

[22] San Camillo Forlanini Hosp, Pediat Unit, Rome, Italy

[23] ASL Crotone, Pediat Unit, Crotone, Italy

[24] St Barbara Hosp, Pediat Unit, Iglesias, Italy

[25] Univ Verona, Dept Life & Reprod Sci, Pediat Sect, Verona, Italy

[26] Grassi Hosp, Pediat Unit, Rome, Italy

[27] G Gaslini Hosp, Pulm Dis & Allergy Unit, Genoa, Italy

[28] Clin San Carlo, Ambula torio Allergol, Paderno Dugnano, Italy

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2024年 / 153卷 / 06期

关键词：

Allergic rhinitis; allergy; asthma; component resolved diagnostics; cross-reactivity; cyclophilins; diagnosis; immunoglobulin E; oral allergy syndrome; panallergens; pollen; precision medicine; COMPONENT-RESOLVED DIAGNOSIS; BETULA-VERRUCOSA POLLEN; PHLEUM-PRATENSE; IMMUNOTHERAPY; SENSITIZATION; IDENTIFICATION; PROFILES; CLONING;

D O I：

10.1016/j.jaci.2024.01.030

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Cyclophilins are ubiquitous panallergens whose epidemiologic, diagnostic, and clinical relevance is largely unknown and whose sensitization is rarely examined in routine allergy practice. Objective: We investigated the epidemiologic, diagnostic, clinical relevance of cyclophilins in seasonal allergic rhinitis its comorbidities. Methods: We examined a random sample of 253 (25%) of Italian children with seasonal allergic rhinitis from the Panallergens in Pediatrics (PAN-PED) cohort with characterized disease phenotypes. Nested studies of sensitization prevalence, correlation, and allergen extract inhibition were performed in patients sensitized to birch pollen extract but lacking IgE to Bet v 1/2/4 (74/1263) or with highest serum of IgE to Bet v 1 (26/1263); and in patients with sensitization various extracts (ragweed, mugwort, pellitory, Plantago , and plane tree), but not to their respective major allergenic molecule, profilins, and polcalcins. IgE to cyclophilin was detected with recombinant Bet v 7, and extract inhibition were performed with the same rBet v 7. Results: IgE to rBet v 7 was detected in 43 (17%) of 253 patients. It was associated with asthma ( P < .028) and oral allergy syndrome (P < .017) in univariate but not multivariate analysis adjusted for IgE to profilins (Phl p 12), PR-10s (Bet v 1), and lipid transfer proteins (Pru p 3). IgE to rBet v 7 was also highly prevalent (47/74, 63%) among patients with unexplained sensitization to birch pollen extract. In patients with unexplained sensitization to ragweed, mugwort, pellitory, Plantago and plane tree pollen, the levels of IgE to those extracts correlated with the levels of IgE to rBet v 7, and they were also significantly inhibited by rBet v 7 (inhibition range 45%-74%). Conclusions: IgE sensitization to cyclophilin is frequent in pollenallergic patients living in temperate areas and can produce "false" positive outcomes in skin prick and IgE tests to pollen extracts. Molecular diagnostic guidelines should include this panallergen family.

引用

页码：1586 / 1596.e2

页数：13

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