Intratumor heterogeneity in EGFR-mutant lung tumors mediates targeted therapy resistance and formation of drug tolerant microenvironment

被引:0
|
作者
Haikala, Heidi M.
Alsaed, Bassel
Son, Jieun
Lin, Linh
Gokhale, Prafulla
Janne, Pasi
机构
关键词
D O I
10.1158/1538-7445.AM2024-1989
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1989
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Activity of erlotinib when dosed below the maximum tolerated dose for EGFR-mutant lung cancer: Implications for targeted therapy development
    Lampson, Benjamin L.
    Nishino, Mizuki
    Dahlberg, Suzanne E.
    Paul, Danie
    Santos, Abigail A.
    Jaenne, Pasi A.
    Oxnard, Geoffrey R.
    CANCER, 2016, 122 (22) : 3456 - 3463
  • [42] Acquired Resistance to EGFR Tyrosine Kinase Inhibitors is Associated With Low Efficacy of Radiation Therapy for Brain Metastases From EGFR-mutant Lung Adenocarcinoma
    Hirata, H.
    Nakamura, K.
    Kunitake, N.
    Shioyama, Y.
    Sasaki, T.
    Nonoshita, T.
    Inoue, K.
    Nagashima, A.
    Ono, M.
    Honda, H.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 84 (03): : S102 - S102
  • [43] Local therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors.
    Yu, Helena Alexandra
    Sima, Camelia S.
    Drilon, Alexander Edward Dela Cruz
    Varghese, Anna M.
    Pietanza, Maria Catherine
    Azzoli, Christopher G.
    Rizvi, Naiyer A.
    Krug, Lee M.
    Kris, Mark G.
    Miller, Vincent A.
    Riely, Gregory J.
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [44] Immune microenvironment change after acquiring resistance to EGFR TKI therapy in EGFR mutant non-small cell lung cancer
    Kim, Tae-Jung
    Kang, Jin-Hyoung
    Hong, Sook-hee
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [45] AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer
    Noronha, Ashish
    Nataraj, Nishanth Belugali
    Lee, Joo Sang
    Zhitomirsky, Benny
    Oren, Yaara
    Oster, Sara
    Lindzen, Moshit
    Mukherjee, Saptaparna
    Will, Rainer
    Ghosh, Soma
    Simoni-Nieves, Arturo
    Verma, Aakanksha
    Chatterjee, Rishita
    Borgoni, Simone
    Robinson, Welles
    Sinha, Sanju
    Brandis, Alexander
    Kerr, D. Lucas
    Wu, Wei
    Sekar, Arunachalam
    Giri, Suvendu
    Chung, Youngmin
    Drago-Garcia, Diana
    Danysh, Brian P.
    Lauriola, Mattia
    Fiorentino, Michelangelo
    Ardizzoni, Andrea
    Oren, Moshe
    Blakely, Collin M.
    Ezike, Jideofor
    Wiemann, Stefan
    Parida, Laxmi
    Bivona, Trever G.
    Aqeilan, Rami, I
    Brugge, Joan S.
    Regev, Aviv
    Getz, Gad
    Ruppin, Eytan
    Yarden, Yosef
    CANCER DISCOVERY, 2022, 12 (11) : 2666 - 2683
  • [46] Next-generation sequencing reveals novel resistance mechanisms and molecular heterogeneity in EGFR-mutant non-small cell lung cancer with acquired resistance to EGFR-TKIs
    Lee, Choong-kun
    Kim, Sora
    Lee, Jae Seok
    Lee, Jeong Eun
    Kim, Sung-moo
    Yang, In Seok
    Kim, Hye Ryun
    Lee, Jeong Ho
    Kim, Sangwoo
    Cho, Byoung Chul
    LUNG CANCER, 2017, 113 : 106 - 114
  • [47] Local Therapy with Continued EGFR Tyrosine Kinase Inhibitor Therapy as a Treatment Strategy in EGFR-Mutant Advanced Lung Cancers That Have Developed Acquired Resistance to EGFR Tyrosine Kinase Inhibitors
    Yu, Helena A.
    Sima, Camelia S.
    Huang, James
    Solomon, Stephen B.
    Rimner, Andreas
    Paik, Paul
    Pietanza, M. Catherine
    Azzoli, Christopher G.
    Rizvi, Naiyer A.
    Krug, Lee M.
    Miller, Vincent A.
    Kris, Mark G.
    Riely, Gregory J.
    JOURNAL OF THORACIC ONCOLOGY, 2013, 8 (03) : 346 - 351
  • [48] Overexpression of Reactive Oxygen Species Modulator 1 Predicts Unfavorable Clinical Outcome in EGFR-Mutant Lung Adenocarcinomas Treated With Targeted Therapy
    Kwack, Won Gun
    Sung, Ji-Youn
    Lee, Seung Hyeun
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [49] Pulse-continuous dose erlotinib as initial targeted therapy for patients with EGFR-mutant lung cancers with untreated brain metastases.
    Kris, Mark G.
    Arbour, Kathryn Cecilia
    Riely, Gregory J.
    Ni, Ai
    Beal, Kathryn
    Daras, Mariza
    Hayes, Sara A.
    Young, Robert J.
    Rodriguez, Christopher R.
    Pao, William
    Yu, Helena Alexandra
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [50] Paradigm shift of therapeutic management of brain metastases in EGFR-mutant non-small cell lung cancer in the era of targeted therapy
    Akimasa Sekine
    Hiroaki Satoh
    Medical Oncology, 2017, 34