Intratumor heterogeneity in EGFR-mutant lung tumors mediates targeted therapy resistance and formation of drug tolerant microenvironment

被引:0
|
作者
Haikala, Heidi M.
Alsaed, Bassel
Son, Jieun
Lin, Linh
Gokhale, Prafulla
Janne, Pasi
机构
关键词
D O I
10.1158/1538-7445.AM2024-1989
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1989
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment
    Alsaed, Bassel
    Lin, Linh
    Son, Jieun
    Li, Jiaqi
    Smolander, Johannes
    Lopez, Timothy
    Eser, Pinar O.
    Ogino, Atsuko
    Ambrogio, Chiara
    Eum, Yoonji
    Thai, Tran
    Wang, Haiyun
    Sutinen, Eva
    Mutanen, Hilma
    Duan, Hanna
    Bobik, Nina
    Borenius, Kristian
    Feng, William W.
    Nabet, Behnam
    Mustjoki, Satu
    Laaksonen, Sanna
    Eschle, Benjamin K.
    Poitras, Michael J.
    Barbie, David
    Ilonen, Ilkka
    Gokhale, Prafulla
    Janne, Pasi A.
    Haikala, Heidi M.
    NATURE COMMUNICATIONS, 2025, 16 (01)
  • [2] Shades of T790M: Intratumor Heterogeneity in EGFR-Mutant Lung Cancer
    Ichihara, Eiki
    Lovly, Christine M.
    CANCER DISCOVERY, 2015, 5 (07) : 694 - 696
  • [3] Overcoming therapy resistance in EGFR-mutant lung cancer
    Antonio Passaro
    Pasi A. Jänne
    Tony Mok
    Solange Peters
    Nature Cancer, 2021, 2 : 377 - 391
  • [4] Overcoming therapy resistance in EGFR-mutant lung cancer
    Passaro, Antonio
    Janne, Pasi A.
    Mok, Tony
    Peters, Solange
    NATURE CANCER, 2021, 2 (04) : 377 - 391
  • [5] Optimizing the Sequence of Anti-EGFR-Targeted Therapy in EGFR-Mutant Lung Cancer
    Meador, Catherine B.
    Jin, Hailing
    de Stanchina, Elisa
    Nebhan, Caroline A.
    Pirazzoli, Valentina
    Wang, Lu
    Lu, Pengcheng
    Vuong, Huy
    Hutchinson, Katherine E.
    Jia, Peilin
    Chen, Xi
    Eisenberg, Rosana
    Ladanyi, Marc
    Politi, Katerina
    Zhao, Zhongming
    Lovly, Christine M.
    Cross, Darren A. E.
    Pao, William
    MOLECULAR CANCER THERAPEUTICS, 2015, 14 (02) : 542 - 552
  • [6] Resistance to Afatinib and Cetuximab Combination Therapy in EGFR-mutant Lung Adenocarcinomas
    Pirazzoli, Valentina
    Takezawa, Ken
    de Stanchina, Elisa
    Pao, William
    Politi, Katerina
    CLINICAL CANCER RESEARCH, 2012, 18 (10)
  • [7] Features of tumor-microenvironment images predict targeted therapy survival benefit in patients with EGFR-mutant lung cancer
    Wang, Shidan
    Rong, Ruichen
    Yang, Donghan M.
    Fujimoto, Junya
    Bishop, Justin A.
    Yan, Shirley
    Cai, Ling
    Behrens, Carmen
    Berry, Lynne D.
    Wilhelm, Clare
    Aisner, Dara
    Sholl, Lynette
    Johnson, Bruce E.
    Kwiatkowski, David J.
    Wistuba, Ignacio I.
    Bunn, Paul A.
    Minna, John
    Xiao, Guanghu
    Kris, Mark G.
    Xie, Yang
    JOURNAL OF CLINICAL INVESTIGATION, 2023, 133 (02):
  • [8] Deep learning radiopathomics predicts targeted therapy sensitivity in EGFR-mutant lung adenocarcinoma
    Taotao Yang
    Xianqi Wang
    Yuan Jin
    Xiaohong Yao
    Zhiyuan Sun
    Pinzhen Chen
    Suyi Zhou
    Wentao Zhu
    Wei Chen
    Journal of Translational Medicine, 23 (1)
  • [9] TARGETED THERAPIES Afatinib-new therapy option for EGFR-mutant lung cancer
    Yu, Helena A.
    Pao, William
    NATURE REVIEWS CLINICAL ONCOLOGY, 2013, 10 (10) : 551 - 552
  • [10] Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer
    Diana Schaufler
    David F. Ast
    Hannah L. Tumbrink
    Nima Abedpour
    Lukas Maas
    Ayla E. Schwäbe
    Inga Spille
    Stefanie Lennartz
    Jana Fassunke
    Mihaela Aldea
    Benjamin Besse
    David Planchard
    Lucia Nogova
    Sebastian Michels
    Carsten Kobe
    Thorsten Persigehl
    Theresa Westphal
    Sophia Koleczko
    Rieke Fischer
    Jan-Phillip Weber
    Janine Altmüller
    Roman K. Thomas
    Sabine Merkelbach-Bruse
    Oliver Gautschi
    Laura Mezquita
    Reinhard Büttner
    Jürgen Wolf
    Martin Peifer
    Johannes Brägelmann
    Matthias Scheffler
    Martin L. Sos
    npj Precision Oncology, 5