Biomimetic mineralization of 3D-printed polyhydroxyalkanoate-based microbial scaffolds for bone tissue engineering

被引：1

作者：

Kim, Dahong ^{[1
,2
]}

Lee, Su Jeong ^{[3
]}

Lee, DongJin ^{[1
]}

Seok, Ji Min ^{[1
,2
]}

Yeo, Seon Ju ^{[1
]}

Lim, Hyungjun ^{[1
]}

Lee, Jae Jong ^{[1
]}

Song, Jae Hwang ^{[4
]}

Lee, Kangwon ^{[2
,5
]}

Park, Won Ho ^{[6
]}

Park, Su A. ^{[1
]}

机构：

[1] Korea Inst Machinery & Mat KIMM, Nanoconvergence Mfg Syst Res Div, Daejeon, South Korea

[2] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Appl Bioengn, Seoul, South Korea

[3] CHA Univ, Dept Microbiol, Seongnam, South Korea

[4] Konyang Univ Hosp, Dept Orthopaed Surg, Daejeon, South Korea

[5] Seoul Natl Univ, Res Inst Convergence Sci, Seoul, South Korea

[6] Chungnam Natl Univ, Dept Organ Mat Engn, Daejeon, South Korea

来源：

INTERNATIONAL JOURNAL OF BIOPRINTING | 2024年 / 10卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Polyhydroxyalkanoate; Biomineralization; Biopolymer; Bone scaffold; Polydopamine; Bioprinting; POLYDOPAMINE; NANOPARTICLES; COATINGS;

D O I：

10.36922/ijb.1806

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Polyhydroxyalkanoates (PHAs) have gained much attention as a potential alternative to conventional plastic bone scaffolds due to their biocompatibility and biodegradability, among a diverse range of advantageous properties. However, the water resistance of PHA creates an environment that can interferewith cell interactions. In this study, a threedimensional-printed PHA scaffold was fabricated through fused deposition modeling printing considering the physical properties of PHA. The PHA bone scaffolds were then coated with polydopamine (pDA) and/or hydroxyapatite (HA) in various configurations using a relatively simple and rapid process involving only immersion. The PHA-pDA- HA scaffold showed enhanced cell viability, proliferation, and differentiation, and could thus serve as a versatile platform for bone tissue engineering applications.

引用

页码：489 / 499

页数：11

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