Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital

被引：1

作者：

Huang, Bin ^{[1
]}

He, Yuting ^{[1
]}

Ma, Xingyan ^{[1
]}

Cai, Renxin ^{[2
,3
]}

Zeng, Jianming ^{[2
,3
]}

Lu, Yang ^{[2
,3
]}

Zhang, Weizheng ^{[2
,3
]}

Lan, Kai ^{[2
,3
]}

E, Sunmei ^{[2
,3
]}

Tang, Yi-Wei ^{[4
]}

Kreiswirth, Barry N. ^{[5
]}

Chen, Cha ^{[2
,3
]}

Chen, Liang ^{[5
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou, Guangdong, Peoples R China

[2] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Lab Med, Guangzhou, Guangdong, Peoples R China

[3] Guangdong Prov Hosp Chinese Med, Dept Lab Med, Guangzhou, Guangdong, Peoples R China

[4] Mem Sloan Kettering Canc Ctr, Dept Lab Med, 1275 York Ave, New York, NY 10021 USA

[5] Rutgers State Univ, New Jersey Med Sch, TB Ctr, Publ Hlth Res Inst, Newark, NJ 07102 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 05期

基金：

中国国家自然科学基金;

关键词：

colistin; genomics; plasmids; promoter; gene expression; RESISTANCE;

D O I：

10.1128/AAC.00018-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Next-generation sequencing of 6 mcr-1-harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence variations significantly affected the expression and promoter activity of mcr-1, the mcr-1 gene expression levels did not correlate with the in vitro colistin resistance levels, which warrants further in-depth investigations.

引用

页数：5

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