Incorporating Fluorescent Organosilica and Zeolitic Imidazolate Frameworks into Periodic Mesoporous Organosilica for the Enhanced Cargo Delivery of 5-Fluorouracil

Nanosized zeolitic imidazolate frameworks (nZIFs) are being researched as 5-fluorouracil (5-FU) carriers for the treatment of cancer. The surface functionalization of ZIFs with periodic mesoporous organosilicas (PMOs) is expected to enhance stability and prevent the flocculation of nZIFs. In this study, ZIF-7 nanomaterials and fluorescent organosilicas (FITC-APTES) were effectively introduced into PMO nanoparticles, and the resulting product was named ZIF-7@PMO. The surface functionalization with the PMO nanoparticles enhanced the chemical stability of ZIF-7 nanoparticles in ethanol. The study examined the impact of temperature on the synthesis of ZIF-7@PMO and found that low temperatures were more conducive to the encapsulation of ZIF-7 nanoparticles and fluorescent organosilica, as well as pore size retention. Moreover, the drug storage capacity of the ZIF-7@PMO nanoparticles was evaluated via their loading and release of 5-FU. The results revealed that the ZIF-7@PMO nanoparticles could adsorb 5-FU with a loading capacity of 100-140 mg g-1 for 24 h. ZIF-7@PMO released half of 5-FU amount within 8 h before releasing a maximum of 75 % within 3 days. Therefore, the fluorescent ZIF-7@PMO nanoparticles could be a potential drug carrier in the field of controlled drug delivery. A multifunctional mesoporous silica hybrid is presented, in which nano ZIF-7 and the conjugated of fluorescein isothiocyanate (FITC) and 3-aminopropyl triethoxysilane (APTES) are introduced into Periodic Mesoporous Organosilica to generate the biodegradable fluorescent nanoparticles for the efficiency release of 5-Fluorouracil. image