Photoredox-Catalyzed Sequential Decarboxylative/Defluorinative Aminoalkylation of CF3-Alkenes with N-Arylglycines

被引：6
|
作者：
Xin, Hong [1 ]
Zhang, Lu [1 ]
Liao, Jinyi [1 ]
Duan, Xin-Hua [1 ,2 ]
Yang, Xu [3 ]
Guo, Li-Na [1 ]
机构：
[1] Xi An Jiao Tong Univ, Minist Educ, Sch Chem, Dept Chem,Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[3] Xi An Jiao Tong Univ, Sch Elect Engn, Xian 710049, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 28期
基金：
中国国家自然科学基金;
关键词：
GEM-DIFLUOROALKENES; BOND ACTIVATION; MONOFLUOROALKENES; DERIVATIVES; ACIDS;
D O I：
10.1021/acs.orglett.4c02154
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A photoredox-catalyzed sequential decarboxylative/defluorinative aminoalkylation of CF3-alkenes with N-arylglycines is described. This metal-free and redox-neutral protocol provided efficient access to the monofluoroalkenyl-1,5-diamines in good yields with excellent functional group compatibility. Mechanistic studies revealed that the reaction proceeds via a radical pathway with the gem-difluoroalkenyl amine as an intermediate.
引用
收藏
页码：6030 / 6034
页数：5
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