C-H fluorination promoted by pyridine N-oxyl radicals

被引：1

作者：

Zeng, Tianyu ^{[1
,2
]}

Huang, Chaoqun ^{[3
,4
]}

Zhang, Yang ^{[1
,2
]}

Luo, Yunzi ^{[3
,4
]}

Niu, Dawen ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Dept Emergency, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Sch Chem Engn, Chengdu 610041, Peoples R China

[3] Tianjin Univ, Sch Chem Engn & Technol, Frontiers Sci Ctr Synthet Biol, Minist Educ, Tianjin 300072, Peoples R China

[4] Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China

来源：

GREEN CHEMISTRY | 2024年 / 26卷 / 15期

基金：

国家重点研发计划;

关键词：

C(SP(3))-H BONDS; ACTIVATION; MONO;

D O I：

10.1039/d4gc02247e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Inspired by C-H hydroxylation by cytochrome P450 enzymes (P450s), we report here a method for preparing organofluorides through a single-electron transfer (SET) process, in which the pyridine N-oxyl radical greatly promotes the C-H fluorination. This reaction can be carried out in pure water at room temperature and accommodates a wide range of substrates, including bioactive molecules, with good yields. Mechanistic investigations indicate that reactions advance through radical intermediates.

引用

页码：8701 / 8705

页数：5

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