Long non-coding RNA HOTAIR: A biomarker and therapeutic target in urological tumors

被引：0
|
作者：
Abida
Eltaib, Lina [2 ]
Alhazmi, Bshayer Hmdan [3 ]
Alzahrani, Abdullah R. [4 ]
Asdaq, Syed Mohammed Basheeruddin [5 ]
Ali, Abuzer [6 ]
Aldhafiri, Futoon Jamal [7 ]
Alruwaili, Wafaa T. [7 ]
Al-Hajeili, Marwan [8 ]
Abdulkhaliq, Altaf A. [9 ]
Rabaan, Ali A. [10 ,11 ,12 ]
Imran, Mohd [1 ,13 ]
机构：
[1] Northern Border Univ, Coll Pharm, Dept Pharmaceut Chem, Rafha 91911, Saudi Arabia
[2] Northern Border Univ, Coll Pharm, Dept Pharmaceut, Rafha 91911, Saudi Arabia
[3] Northern Area Armed Forces Hosp, Dept Pharm, Hafer Al Batin 39745, Saudi Arabia
[4] Umm Al Qura Univ, Fac Med, Dept Pharmacol & Toxicol, POB 13578, Mecca 21955, Saudi Arabia
[5] AlMaarefa Univ, Coll Pharm, Dept Pharm Practice, Riyadh 13713, Saudi Arabia
[6] Taif Univ, Coll Pharm, Dept Pharmacognosy, POB 11099, Taif 21944, Saudi Arabia
[7] Northern Border Univ, Coll Pharm, Rafha 91911, Saudi Arabia
[8] King Abdulaziz Univ, Dept Med, Jeddah 23624, Saudi Arabia
[9] Umm Al Qura Univ, Fac Med, Dept Biochem, Mecca 21955, Saudi Arabia
[10] Johns Hopkins Aramco Healthcare, Mol Diagnost Lab, Dhahran 31311, Saudi Arabia
[11] Alfaisal Univ, Coll Med, Riyadh 11533, Saudi Arabia
[12] Univ Haripur, Dept Publ Hlth & Nutr, Haripur 22610, Pakistan
[13] Northern Border Univ, Ctr Hlth Res, Ar Ar, Saudi Arabia
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 262卷
关键词：
HOTAIR; Urologic cancer; Kidney; Bladder; Long non coding RNA; PROSTATE-CANCER; LNCRNA HOTAIR; UP-REGULATION; ENHANCES RADIOSENSITIVITY; DRUG-RESISTANCE; LUNG-CANCER; CHROMATIN; TRANSCRIPTION; PRC2; LANDSCAPE;
D O I：
10.1016/j.prp.2024.155549
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Long non-coding RNAs (lncRNAs) significantly influence gene regulation across epigenetic, transcriptional, and post-transcriptional levels through their interactions with DNA, RNA, and proteins. There is growing evidence of lncRNAs' critical roles in the emergence and progression of various diseases, including urological tumors (UTs), such as cancers of the kidney, bladder, and prostate. Research increasingly links lncRNA dysregulation to diverse cellular processes like invasion, metastasis, apoptosis, and chromatin remodeling. Among these, HOTAIR stands out for its pivotal role in oncogenesis, impacting treatment resistance, cell migration, proliferation, survival, and genomic integrity. This review provides an overview of HOTAIR's functions, its identification, and its biological significance. Furthermore, it delves into HOTAIR's involvement in UTs, underlining its potential as a therapeutic target and biomarker for innovative approaches to treating these cancers.
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页数：10
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