Non-human primates, due to their similarities in immune response to humans, are the preferred model for studying infectious processes and any associated cognitive impairments. Behavioral tests are indispensable for investigating pathogenesis in neuroinfections, especially those that do not manifest with noticeable clinical symptoms, as well as in the transition to a chronic form of the disease. Modeling viral infection requires specialized experimental conditions. Our work describes techniques for investigating mnemonic functions, tiredness, attentional focus, quick-wittedness, and basic behavioral responses in primates under the assumed conditions for infections with viruses that do not have an airborne route of transmission. It also outlines approaches to the training and selection of primates for virological research, as well as analyzing gender differences in learning abilities, the impact of housing conditions on the results, and the correlation between training success and behavioral test scores. These methods will allow a more detailed study of non-human primates as a model for researching cognitive and behavioral impairments under infectious and immune stress, as well as the design of less energy-intensive experiments for evaluating the efficacy and safety of therapeutic and prophylactic strategies at early stages of infection.
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Shiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Sato, Akira
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Tsukiyama, Tomoyuki
Komeno, Masahiro
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Shiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Komeno, Masahiro
Iwatani, Chizuru
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Shiga Univ Med Sci, Res Ctr Anim Life Sci, Otsu, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Iwatani, Chizuru
Tsuchiya, Hideaki
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Shiga Univ Med Sci, Res Ctr Anim Life Sci, Otsu, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Tsuchiya, Hideaki
Kawamoto, Ikuo
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Shiga Univ Med Sci, Res Ctr Anim Life Sci, Otsu, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Kawamoto, Ikuo
Murase, Mitsuru
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Shiga Univ Med Sci, Res Ctr Anim Life Sci, Otsu, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Murase, Mitsuru
Nakagawa, Takahiro
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Shiga Univ Med Sci, Res Ctr Anim Life Sci, Otsu, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Nakagawa, Takahiro
Itagaki, Iori
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Shiga Univ Med Sci, Res Ctr Anim Life Sci, Otsu, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Itagaki, Iori
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Seita, Yasunari
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Matsumoto, Shoma
Nakaya, Masataka
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Shiga Univ Med Sci, Res Ctr Anim Life Sci, Otsu, Japan
Kyoto Univ, Inst Adv Study Human Biol WPI ASHBi, Kyoto, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
Nakaya, Masataka
Shimizu, Akio
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Shiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, JapanShiga Univ Med Sci, Div Mol Med Biochem, Dept Biochem & Mol Biol, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan
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Bayer HealthCare, Global Drug Discovery, D-13342 Berlin, GermanyBayer HealthCare, Global Drug Discovery, D-13342 Berlin, Germany
Gashaw, I.
Harirchian, P.
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Bayer HealthCare, Global Drug Discovery, D-13342 Berlin, GermanyBayer HealthCare, Global Drug Discovery, D-13342 Berlin, Germany
Harirchian, P.
Lipskind, S.
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Brigham & Womens Hosp, Boston, MA 02115 USABayer HealthCare, Global Drug Discovery, D-13342 Berlin, Germany
Lipskind, S.
Braundmeier, A.
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Univ Illinois, Urbana, IL 61801 USABayer HealthCare, Global Drug Discovery, D-13342 Berlin, Germany
Braundmeier, A.
Hastings, J. M.
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Univ Edinburgh, Edinburgh, Midlothian, ScotlandBayer HealthCare, Global Drug Discovery, D-13342 Berlin, Germany
Hastings, J. M.
Olson, M.
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Michigan State Univ, Coll Human Med, Dept Ob Gyn & Reprod Biol, E Lansing, MI 48824 USABayer HealthCare, Global Drug Discovery, D-13342 Berlin, Germany
Olson, M.
Fazleabas, A. T.
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Michigan State Univ, Coll Human Med, Dept Ob Gyn & Reprod Biol, E Lansing, MI 48824 USABayer HealthCare, Global Drug Discovery, D-13342 Berlin, Germany