Diabetes Pharmacotherapy and its effects on the Skeletal Muscle Energy Metabolism

被引：1

作者：

Yu, Baowen ^{[1
]}

Wang, Dong ^{[2
]}

Zhou, Junming ^{[3
]}

Huang, Rong ^{[1
]}

Cai, Tingting ^{[1
]}

Hu, Yonghui ^{[1
]}

Zhou, Yunting ^{[1
]}

Ma, Jianhua ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Endocrinol, Nanjing, Jiangsu, Peoples R China

[2] Southeast Univ, Nanjing Tongren Hosp, Sch Med, Dept Otolaryngol Head & Neck, Nanjing, Peoples R China

[3] Nanjing Univ, Jinling Hosp, Dept Cadre Gastroenterol, Med Sch, Nanjing, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2024年 / 24卷 / 16期

关键词：

Type 2 diabetes mellitus; skeletal muscle; mitochondria; metformin; insulin; postprandial glucose; PEPTIDE-1 RECEPTOR AGONISTS; INSULIN-RESISTANCE; MITOCHONDRIAL-FUNCTION; GLUCOSE-UPTAKE; SERUM IRISIN; METFORMIN; MASS; ACTIVATION; MICROVASCULATURE; ROSIGLITAZONE;

D O I：

10.2174/0113895575299439240216081711

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The disorders of skeletal muscle metabolism in patients with Type 2 diabetes mellitus (T2DM), such as mitochondrial defection and glucose transporters (GLUTs) translocation dysfunctions, are not uncommon. Therefore, when anti-diabetic drugs were used in various chronic diseases associated with hyperglycemia, the impact on skeletal muscle should not be ignored. However, current studies mainly focus on muscle mass rather than metabolism or functions. Anti-diabetic drugs might have a harmful or beneficial impact on skeletal muscle. In this review, we summarize the up-to-date studies on the effects of anti-diabetic drugs and some natural compounds on skeletal muscle metabolism, focusing primarily on emerging data from pre-clinical to clinical studies. Given the extensive use of anti-diabetic drugs and the common sarcopenia, a better understanding of energy metabolism in skeletal muscle deserves attention in future studies.

引用

页码：1470 / 1480

页数：11

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