IL-7 and IL-7R in health and disease: An update through COVID times

被引：4

作者：

Fernandes, Marta B. ^{[1
]}

Barata, Joao T. ^{[1
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Med Mol Joa Lobo Antunes, Ave Prof Egas Moniz, P-1649028 Lisbon, Portugal

来源：

ADVANCES IN BIOLOGICAL REGULATION | 2023年 / 87卷

基金：

欧洲研究理事会;

关键词：

D O I：

10.1016/j.jbior.2022.100940

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of IL-7 and IL-7R for normal lymphoid development and an adequately functioning immune system has been recognized for long, with severe immune deficiency and lymphoid leukemia as extreme examples of the consequences of deregulation of the IL-7-IL-7R axis. In this review, we provide an update (focusing on the past couple of years) on IL-7 and IL-7R in health and disease. We highlight the findings on IL-7/IL-7R signaling mechanisms and the, sometimes controversial, impact of IL-7 and its receptor on leukocyte biology, COVID-19, acute lymphoblastic leukemia, and different solid tumors, as well as their relevance as therapeutic tools or targets.

引用

页数：10

共 50 条

[41] Transcriptional regulation of the IL-7Rα gene by dexamethasone and IL-7 in primary human CD8 T cells
Kakal, Juzer A.
Ghazawi, Feras M.
Faller, Elliott M.
Sugden, Scott M.
Parmar, Parmvir
MacPherson, Paul A.
IMMUNOGENETICS, 2017, 69 (01) : 13 - 27
[42] Control of IL-7 responsiveness through IL-7R subunits balance in effector T cells and analytic expressions for amplitude and EC50
Sta, Lea
Voisinne, Guillaume
Cotari, Jesse
Bonnet, Gregoire Altan
EUROPEAN JOURNAL OF IMMUNOLOGY, 2021, 51 : 215 - 215
[43] IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells
Nodland, Sonja E.
Berkowska, Magdalena A.
Bajer, Anna A.
Shah, Nisha
de Ridder, Dick
van Dongen, Jacques J. M.
LeBien, Tucker W.
van Zelm, Menno C.
BLOOD, 2011, 118 (08) : 2116 - 2127
[44] APOE ε4-associated downregulation of the IL-7/IL-7R pathway in effector memory T cells: Implications for Alzheimer's disease
Zhang, Ying-Jie
Cheng, Yan
Tang, Hai-Liang
Yue, Qi
Cai, Xin-Yi
Lu, Zhi-Jie
Hao, Yi-Xuan
Dai, An-Xiang
Hou, Ting
Liu, Hao-Xin
Kong, Nan
Ji, Xiao-Yu
Lu, Chang-Hao
Xu, Sheng-Liang
Huang, Kai
Zeng, Xin
Wen, Ya-Qi
Ma, Wan-Yin
Guan, Ji-Tian
Lin, Yan
Zheng, Wen-Bin
Pan, Hui
Wu, Jie
Wu, Ren-Hua
Wei, Nai-Li
ALZHEIMERS & DEMENTIA, 2024, 20 (09) : 6441 - 6455
[45] The pivotal role of Il-7/Il-7r-dependent signaling pathway for expansion of highly Il-7r expressing mucosal T cells and development of chronic colitis
Okada, E
Yamazaki, M
Nakamura, T
Kanai, T
Tanabe, M
Takeuchi, T
Watanabe, M
GASTROENTEROLOGY, 2004, 126 (04) : A426 - A426
[46] Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis
Natale, Maria A.
Cesar, Gonzalo A.
Alvarez, Maria G.
Castro Eiro, Melisa D.
Lococo, Bruno
Bertocchi, Graciela
Albareda, Maria C.
Laucella, Susana A.
PLOS NEGLECTED TROPICAL DISEASES, 2018, 12 (12):
[47] Increased Bone Marrow Interleukin-7 (IL-7)/IL-7R Levels but Reduced IL-7 Responsiveness in HIV-Positive Patients Lacking CD4+Gain on Antiviral Therapy
Bellistri, Giusi Maria
Casabianca, Anna
Merlini, Esther
Orlandi, Chiara
Ferrario, Giulio
Meroni, Luca
Galli, Massimo
Magnani, Mauro
Monforte, Antonella d'Arminio
Marchetti, Giulia
PLOS ONE, 2010, 5 (12):
[48] IL-7Rα and multiple sclerosis risk
John B Harley
Nature Genetics, 2007, 39 : 1053 - 1054
[49] Targeting the IL-7R pathway in leukemia
Durum, Scott
Hixon, Julie
Senkevitch, Emilee
Cramer, Sarah
Barata, Joao
Walsh, Scott
Li, Wenqing
CYTOKINE, 2017, 100 : 181 - 181
[50] Role of CXCR3 Ligands in IL-7/IL-7Rα-Fc-Mediated Antitumor Activity in Lung Cancer
Andersson, Asa
Srivastava, Minu K.
Harris-White, Marni
Huang, Min
Zhu, Li
Elashoff, David
Strieter, Robert M.
Dubinett, Steven M.
Sharma, Sherven
CLINICAL CANCER RESEARCH, 2011, 17 (11) : 3660 - 3672

← 1 2 3 4 5 →