IL-7 and IL-7R in health and disease: An update through COVID times

被引：4
|
作者：
Fernandes, Marta B. [1 ]
Barata, Joao T. [1 ]
机构：
[1] Univ Lisbon, Fac Med, Inst Med Mol Joa Lobo Antunes, Ave Prof Egas Moniz, P-1649028 Lisbon, Portugal
来源：
ADVANCES IN BIOLOGICAL REGULATION | 2023年 / 87卷
基金：
欧洲研究理事会;
关键词：
D O I：
10.1016/j.jbior.2022.100940
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of IL-7 and IL-7R for normal lymphoid development and an adequately functioning immune system has been recognized for long, with severe immune deficiency and lymphoid leukemia as extreme examples of the consequences of deregulation of the IL-7-IL-7R axis. In this review, we provide an update (focusing on the past couple of years) on IL-7 and IL-7R in health and disease. We highlight the findings on IL-7/IL-7R signaling mechanisms and the, sometimes controversial, impact of IL-7 and its receptor on leukocyte biology, COVID-19, acute lymphoblastic leukemia, and different solid tumors, as well as their relevance as therapeutic tools or targets.
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页数：10
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