Participation of preovulatory follicles in the activation of primordial follicles in mouse ovaries

被引:1
|
作者
Zhang, Jingwen [1 ]
Xia, Wenzhe [1 ]
Zhou, Jiaqi [1 ,2 ]
Qin, Shaogang [1 ]
Lin, Lin [1 ]
Zhao, Ting [1 ]
Wang, Huarong [1 ,3 ]
Mi, Chen [1 ]
Hu, Yifan [1 ]
Chen, Zixuan [1 ,4 ]
Zhu, Tianhua [1 ]
Yang, Xinyu [1 ]
Zhang, Tuo [1 ,5 ]
Xia, Guoliang [1 ]
Ke, Yuwen [1 ]
Wang, Chao [1 ]
机构
[1] China Agr Univ, Coll Biol Sci, State Key Lab Anim Biotech Breeding, Beijing 100193, Peoples R China
[2] Shandong Univ Technol, Sch Life Sci & Med, Zibo 255049, Shandong, Peoples R China
[3] Guangzhou Med Univ, Dept Obstet & Gynecol, Key Lab Major Obstet Dis Guangdong Prov, Affiliated Hosp 3, Guangzhou 510000, Peoples R China
[4] Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China
[5] Guizhou Med Univ, Transformat Engn Res Ctr Chron Dis Diag & Treatmen, Dept Physiol, Coll Basic Med, Guiyang 550025, Guizhou, Peoples R China
来源
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2024年 / 20卷 / 10期
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
Ovulation; primordial follicle activation; extracellular matrix; Cathepsin L; CELLS; OVULATION; FOLLICULOGENESIS; SPECIFICITY; SUPPRESSION; FERTILITY; FOXO3;
D O I
10.7150/ijbs.95020
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The mechanisms behind the selection and initial recruitment of primordial follicles (PmFs) from the non-growing PmF pool during each estrous cycle in females remain largely unknown. This study demonstrates that PmFs closest to the ovulatory follicle are preferentially activated in mouse ovaries under physiological conditions. PmFs located within 40 mu m of the ovulatory follicles were more likely to be activated compared to those situated further away during the peri-ovulation period. Repeated superovulation treatments accelerated the depletion of the PmF reserve, whereas continuous suppression of ovulation delayed PmF reserve consumption. Spatial transcriptome sequencing of peri-ovulatory follicles revealed that ovulation primarily induces the degradation and remodeling of the extracellular matrix (ECM). This ECM degradation reduces mechanical stress around PmFs, thereby triggering their activation. Specifically, Cathepsin L (CTSL), a cysteine proteinase and lysosomal enzyme involved in ECM degradation, initiates the activation of PmFs adjacent to ovulatory follicles in a distance-dependent manner. These findings highlight the link between ovulation and selective PmF activation, and underscore the role of CTSL in this process under physiological conditions.
引用
收藏
页码:3863 / 3880
页数:18
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