Anti-tumor activity in preclinical models utilizing a conditional bispecific redirected activation molecule (COBRA) targeting Her2

被引：1
|
作者：
Stringer, Bradley
Chouitar, Johara
Cerbone, Jacqualine
Fortin, Sarah
Ainbinder, Alina
Kysilovsky, Cassie
Scott, Brittany
Banerjee, Antara
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2024-LB063
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LB063
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy
    Garcia-Garcia, Celina
    Ibrahim, Yasir H.
    Serra, Violeta
    Teresa Calvo, Maria
    Guzman, Marta
    Grueso, Judit
    Aura, Claudia
    Perez, Jose
    Jessen, Katti
    Liu, Yi
    Rommel, Christian
    Tabernero, Josep
    Baselga, Jose
    Scaltriti, Maurizio
    CLINICAL CANCER RESEARCH, 2012, 18 (09) : 2603 - 2612
  • [42] Preclinical activity of ELVN-002: A potent, selective, and irreversible HER2 and pan-HER2 mutant small molecule inhibitor for the treatment of HER2 driven malignancies
    Aujay, Monette
    Broad, Amanda J.
    Gross, Stefan D.
    Ren, Li
    Lyssikatos, Joseph P.
    Kintz, Samuel
    Wang, Qi
    Collins, Helen
    CANCER RESEARCH, 2023, 83 (07)
  • [43] A bispecific T cell engager targeting CEACAM5/6 exhibits strong anti-tumor efficacy in preclinical studies.
    Chen, Liandi
    Huang, Weifeng
    Miao, Xiaoniu
    Si, Jiayi
    Wang, Chao
    Dong, Tiantian
    Tsun, Andy
    Luo, Yi
    CANCER RESEARCH, 2022, 82 (12)
  • [44] Targeting HER2 and FGFR-positive cancer cells with a bispecific cytotoxic conjugate combining anti-HER2 Affibody and FGF2
    Krzyscik, Mateusz A.
    Porebska, Natalia
    Opalinski, Lukasz
    Otlewski, Jacek
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 254
  • [45] A novel HER2/4-1BB bispecific antibody, YH32367 (ABL105) exerts significant anti-tumor effects through tumor-directed T cell activation
    Lee, E.
    Chung, H.
    Lee, Y.
    Lee, E-J.
    Park, Y. B.
    Kim, Y.
    Park, J. Y.
    Ahn, S.
    Kim, J.
    Ahn, K. K.
    Park, K.
    Son, W.
    Yeom, D.
    Jung, J.
    Won, J.
    Oh, S.
    ANNALS OF ONCOLOGY, 2021, 32 : S607 - S608
  • [46] A novel HER2/4-1BB bispecific antibody, YH32367 (ABL105) shows potent anti-tumor effect through tumor-directed T cell activation
    Song, Moo Young
    Lee, Eun-Jung
    Chung, Hyejin
    Lee, Yangsoon
    Park, Young Bong
    Jee, Min Hyeok
    Kim, KyeongBae
    Ju, Mikyeong
    Lee, Jun Kyung
    Choi, Byung Hyun
    Park, Ju Young
    Kim, DaeWon
    Kim, Junhwan
    Ahn, Sujin
    Ahn, Kyoung Kyu
    Park, Kyeongsu
    Jung, Uijung
    Son, Wonjun
    Eom, Jaehyun
    Kim, Eunjung
    Yeom, Donghoon
    Ahn, Jinhyung
    Song, Daehae
    Sung, Byungje
    You, Weon-kyoo
    Kim, Jong Gyun
    Oh, Se-Woong
    Jung, Jaeho
    CANCER RESEARCH, 2020, 80 (16)
  • [47] MM-111, a bispecific HER2 and HER3 antibody, synergistically combines with trastuzumab and paclitaxel in preclinical models of gastric cancer.
    Zhang, Bo
    Lahdenranta, Johanna
    Du, Jinyan
    Kirouac, Daniel
    Stephanie Nguyen
    Overland, Ryan
    Paragas, Violette
    Kudla, Arthur
    Nielsen, Ulrik
    McDonagh, Charlotte
    Onsum, Matthew
    CANCER RESEARCH, 2013, 73 (08)
  • [48] Aggregation of HER2 receptors on the tumor cell surface induced by a novel anti-HER2 bispecific antibody led to enhanced tumor cell growth inhibition
    Deng, Lan
    Zhao, Jie
    Meng, Xiaoqing
    Xiao, Aotian
    Zhu, Zhenping
    Huang, Haomin
    CANCER RESEARCH, 2022, 82 (12)
  • [49] Targeting TBL1 with tegavivint promotes anti-tumor and immunomodulatory responses in preclinical models of hepatocellular carcinoma
    Holloway, Kimberly R.
    Drake, Thomas
    Bird, Thomas
    Horrigan, Stephen
    CANCER RESEARCH, 2023, 83 (07)
  • [50] Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activity
    Wang, Lei
    Zhou, Xusha
    Zou, Weixuan
    Wu, Yinglin
    Zhao, Jing
    Chen, Xiaoqing
    Zhou, Grace Guoying
    JOURNAL OF NANOBIOTECHNOLOGY, 2020, 18 (01)
12345