Pd(II)/LA-Catalyzed Intramolecular Hydroarylation of Alkynoates to Construct Coumarins

被引：1

作者：

Dong, Shuangfeng ^{[1
]}

Li, Kaiwen ^{[1
]}

Li, Shuang-Long ^{[1
]}

Chen, Zhuqi ^{[1
]}

Yin, Guochuan ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Key Lab Mat Chem Energy Convers & Storage, Hubei Key Lab Mat Chem & Serv Failure, Sch Chem & Chem Engn,Minist Educ, Wuhan 430074, Peoples R China

来源：

CHEMISTRYSELECT | 2024年 / 9卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Heterobimetallic catalyst; Coumarins; Hydroarylation; Palladium(II); and Lewis acids; H BOND ACTIVATION; FUNCTIONALIZATION; DERIVATIVES; CATALYSIS; TEMPLATE; ALKYNES; ARYL;

D O I：

10.1002/slct.202401710

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transition-metal ions catalyzed intramolecular hydroarylation of aryl alkynoates to construct coumarin skeletons is merited for its step and atom-economic advantages when compared with other methodologies. The challenge is that the electrophilic cyclization of this reaction requires the strong electrophilic capability of the catalyst, which makes this methodology was seldomly developed after its early explorations. Herein, we report a Lewis acid promoted Pd(II)-catalyzed intramolecular hydroarylation to construct coumarin and its derivatives; the linkage of Lewis acid to the Pd(II) species through diacetate bridge improved its electrophilic capability, facilitating the hydroarylation reaction happening under the neutral conditions. Linkage of Lewis acid to the Pd(II) species through diacetate bridge can improve its electrophilicity, facilitating the Pd(II)-catalzyed intramolecular hydroarylation of alkynoates to construct coumarins under neutral conditions. image

引用

页数：6

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