Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06

被引：0

作者：

Zhang, Hui ^{[1
,2
,3
]}

Wang, Zhen-yu ^{[3
]}

Qi, Huan ^{[3
]}

Zhang, Shao-yong ^{[3
]}

Huang, Jun ^{[4
]}

Wang, Ji-dong ^{[3
]}

Xiang, Wen-sheng ^{[1
]}

机构：

[1] Northeast Agr Univ, Life Sci & Biotechnol Res Ctr, Sch Life Sci, Harbin 150030, Peoples R China

[2] Taizhou Vocat Coll Sci & Technol, Sch Agr & Bioengn, Key Lab Hort Biotechnol Taizhou, Taizhou 318020, Peoples R China

[3] HuZhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control, Huzhou 313000, Peoples R China

[4] Zhejiang Makohs Biotech Co Ltd, Taizhou 318000, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2024年 / 77卷 / 10期

关键词：

IVERMECTIN;

D O I：

10.1038/s41429-024-00754-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from the fermentation broth of Streptomyces avermitilis HU02-06. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data. Bioassay test showed that these two new tenvermectins exhibited weak nematocidal activity against Bursaphelenchus xylophilus and moderate cytotoxic activity against tumor cell lines HepG2 and HCT116.

引用

页码：653 / 656

页数：4

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