Platelet Fcγ RIIA: An emerging regulator and biomarker in cardiovascular disease and cancer

被引：2
|
作者：
Zhang, Qingsong [1 ]
Li, Wenxian [1 ]
Mao, Xin [1 ]
Miao, Shuo [2 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Dept Urol, Qingdao, Peoples R China
[2] Qingdao Univ, Sch Basic Med, Qingdao, Peoples R China
来源：
THROMBOSIS RESEARCH | 2024年 / 238卷
关键词：
Platelet; Fc gamma RIIA; Cardiovascular disease; cancer; MONOCLONAL-ANTIBODIES; RECEPTOR EXPRESSION; IMMUNE-COMPLEXES; IMMUNOGLOBULIN-G; TRANSGENIC MICE; ACTIVATION; THROMBOSIS; COLLAGEN; BINDING; IDENTIFICATION;
D O I：
10.1016/j.thromres.2024.04.014
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelets, anucleate blood cells derive from megakaryocytes, are involved in cardiovascular diseases and tumors. Fc gamma RIIA, the only Fc gamma R expressed on human platelets, is known for its role in immune-related diseases. A growing body of evidence reveals that platelet Fc gamma RIIA is a potential target for the prevention and control of cardiovascular disease and cancer, and is an advantageous biomarker. In this review, we describe the structure and physiological function of platelet Fc gamma RIIA, its regulatory role in cardiovascular disease and cancer, and its potential clinical application.
引用
收藏
页码：19 / 26
页数：8
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