Glycerol: A green solvent for synthetic chemistry

被引：5

作者：

de Oliveira, Alex de Nazare ^{[1
,2
]}

Melchiorre, Massimo ^{[3
,4
]}

da Costa, Ana Alice Farias ^{[1
]}

da Silva, Lineia Soares ^{[5
]}

Paiva, Rutileia de Jesus ^{[6
]}

Auvigne, Amelie ^{[7
]}

Ouyang, Weiyi ^{[8
]}

Luque, Rafael ^{[9
,10
]}

da Rocha Filho, Geraldo Narciso ^{[1
]}

Noronha, Renata Coelho Rodrigues ^{[11
]}

Esposito, Roberto ^{[3
]}

do Nascimento, Luis Adriano Santos ^{[1
,5
]}

Len, Christophe ^{[8
,12
,13
]}

机构：

[1] Fed Univ Para, Grad Program Chem, Augusto Correa St, BR-66075110 Belem, PA, Brazil

[2] Univ Fed Amapa, Biocatalysis & Appl Organ Synth Grp, Chem Course, Campus Marco Zero Equador,Rodovia Josmar Chaves Pi, BR-68903419 Macapa, AP, Brazil

[3] Univ Federico II, Dept Chem Sci, Complesso Univ Monte S Angelo,Via Cintia 21, I-80126 Naples, Italy

[4] ISUSCHEM Srl, Piazza Carita 32, I-80134 Naples, Italy

[5] Fed Inst Educ Sci & Technol Amapa, BR-68909398 Macapa, AP, Brazil

[6] Fed Univ Para, Inst Biol Sci, Grad Program Biotechnol, Augusto Correa St, BR-66075110 Guama, PA, Brazil

[7] THALES AVS, Microwave & Imaging Subsyst, 2 Rue Marcel Dassault, F-78140 Velizy Villacoublay, France

[8] Xi An Jiao Tong Univ, Sch Chem, 28 Xianning West Rd, Xian 710049, Peoples R China

[9] RUDN Univ, Peoples Friendship Univ Russia, 6 Miklukho Maklaya Str, Moscow 117198, Russia

[10] Univ ECOTEC, Km 13-5 Samborondon, EC-0922302 Samborondon, Ecuador

[11] Fed Univ Para, Inst Biol Sci, Ctr Estudos Avancados Biodiversidade, Lab Genet & Biol Celular, Augusto Correa St,Guama, BR-66075110 Belem, PA, Brazil

[12] PSL Res Univ, Inst Chem Life & Hlth Sci, Chim ParisTech, CNRS, F-75005 Paris, France

[13] Univ Technol Compiegne, Sorbonne Univ, Ctr Rech Royallieu, CS 60319, F-60203 Compiegne, France

来源：

SUSTAINABLE CHEMISTRY AND PHARMACY | 2024年 / 41卷

关键词：

Glycerol; Green solvent; Green chemistry; Organic syntheses; Catalysis; Sustainability; CATALYST-FREE SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; CROSS-COUPLING REACTIONS; ONE-POT SYNTHESIS; RECYCLABLE SOLVENT; MULTICOMPONENT REACTIONS; PALLADIUM NANOPARTICLES; CONVENIENT SYNTHESIS; EFFICIENT CATALYST; VINYL SULFIDES;

D O I：

10.1016/j.scp.2024.101656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Glycerol is a biobased, biodegradable liquid known for its non-toxic, non-hazardous, non-volatile, and water-soluble properties, making it valuable in various applications. Derived from biodiesel production, it constitutes about 10% of the weight alongside fatty acid alkyl esters. Its availability and unique properties make glycerol an economically attractive and safe solvent for organic syntheses. Solvents, critical in chemical processes, require recycling or disposal, often via incineration. Eco-friendly profile of glycerol offers significant advantages over traditional solvents. Research has highlighted the role of glycerol as a hydrogen donor in metal-catalyzed transfer hydrogenation reactions, reducing compounds and aiding in metal nanoparticle preparation. Since 2010, glycerol has been recognized for its solvent capabilities in key organic reactions, such as C-C bond formations (e.g., Suzuki-Miyaura, Heck-Mizoroki), C-N, and C-P bond formations, among others. It also facilitates multicomponent reactions, showing high yields with various catalyst systems. The potential of glycerol extends to catalyst recyclability and sustainability in chemical processes. However, more systematic studies and modeling are needed to fully leverage its benefits. Exploring the use of crude glycerol could enhance cost-effectiveness and sustainability, and transitioning to continuous flow systems could improve productivity. Addressing these aspects can lead to broader and more sustainable glycerol utilization in the future.

引用

页数：75

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