A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

被引:0
|
作者
Neagu, Anca-Narcisa [1 ]
Jayaweera, Taniya [2 ]
Weraduwage, Krishan [2 ]
Darie, Costel C. [2 ]
机构
[1] Alexandru Ioan Cuza Univ, Fac Biol, Lab Anim Histol, Carol 1bvd 20A, Iasi 700505, Romania
[2] Clarkson Univ, Dept Chem & Biochem, Biochem & Prote Labs, Potsdam, NY 13699 USA
基金
美国国家卫生研究院;
关键词
breast cancer (BC); nanorobots; nanobiomedicine; nano-theranostics; DRUG-DELIVERY; NANOPARTICLES; HALLMARKS; NANOMEDICINE; APOPTOSIS; THERAPY; CELLS; NANOPLATFORM; AUTOPHAGY; EVASION;
D O I
10.3390/ijms25094981
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating in nanorobots, have demonstrated ingenious applications in biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem of BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies and real-time monitoring of tumors, nanorobots are designed to perform multiple tasks at a small scale, even at the organelles or molecular level. Over the last few years, most nanorobots have been bioengineered as biomimetic and biocompatible nano(bio)structures, resembling different organisms and cells, such as urchin, spider, octopus, fish, spermatozoon, flagellar bacterium or helicoidal cyanobacterium. In this review, readers will be able to deepen their knowledge of the structure, behavior and role of several types of nanorobots, among other nanomaterials, in BC theranostics. We summarized here the characteristics of many functionalized nanodevices designed to counteract the main neoplastic hallmark features of BC, from sustaining proliferation and evading anti-growth signaling and resisting programmed cell death to inducing angiogenesis, activating invasion and metastasis, preventing genomic instability, avoiding immune destruction and deregulating autophagy. Most of these nanorobots function as targeted and self-propelled smart nano-carriers or nano-drug delivery systems (nano-DDSs), enhancing the efficiency and safety of chemo-, radio- or photodynamic therapy, or the current imagistic techniques used in BC diagnosis. Most of these nanorobots have been tested in vitro, using various BC cell lines, as well as in vivo, mainly based on mice models. We are still waiting for nanorobots that are low-cost, as well as for a wider transition of these favorable effects from laboratory to clinical practice.
引用
收藏
页数:27
相关论文
共 50 条
  • [1] Nanotechnology: A revolutionary approach to prevent breast cancer recurrence
    Alshareeda, Alaa T.
    Khatijah, M. Z. Nur
    Al-Sowayan, Batla S.
    [J]. ASIAN JOURNAL OF SURGERY, 2023, 46 (01) : 13 - 17
  • [2] Nanotechnology-based Approaches for Breast Cancer
    Prabha, Shashi
    Panda, Pritish Kumar
    Singh, Sumita
    Ahmed, Bahar
    [J]. CURRENT CANCER THERAPY REVIEWS, 2024,
  • [3] A silicon photonics approach for the nanotechnology era
    Ohashi, K.
    Nishi, K.
    Shimizu, T.
    Nakada, M.
    Fujikata, J.
    Ushida, J.
    Gomyo, A.
    Ishi, T.
    Nose, K.
    Mizuno, M.
    Kinoshita, M.
    Suzuki, N.
    Okamoto, D.
    Yukawa, H.
    Tsuchizawa, T.
    Watanabe, T.
    Yamada, K.
    Itabashi, S.
    Akedo, J.
    [J]. 2007 IEEE INTERNATIONAL ELECTRON DEVICES MEETING, VOLS 1 AND 2, 2007, : 787 - +
  • [4] Nanotechnology-based Therapeutic Strategies for Breast Cancer
    Aljadani, Majidah
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION, 2022, 12 (02) : 145 - 150
  • [5] Advancing Era and Rising Concerns in Nanotechnology-Based Cancer Treatment
    Tiwari, Harshita
    Gupta, Priyamvada
    Verma, Ashish
    Singh, Swati
    Kumar, Rajiv
    Gautam, Hemant Kumar
    Gautam, Vibhav
    [J]. ACS CHEMICAL HEALTH & SAFETY, 2024, 31 (02) : 153 - 161
  • [6] Impact of nanotechnology in breast cancer
    Haq, Asif I.
    Zabkiewicz, Catherine
    Grange, Philippe
    Arya, Manit
    [J]. EXPERT REVIEW OF ANTICANCER THERAPY, 2009, 9 (08) : 1021 - 1024
  • [7] Nanotechnology for breast cancer therapy
    Takemi Tanaka
    Paolo Decuzzi
    Massimo Cristofanilli
    Jason H. Sakamoto
    Ennio Tasciotti
    Fredika M. Robertson
    Mauro Ferrari
    [J]. Biomedical Microdevices, 2009, 11 : 49 - 63
  • [8] Nanotechnology for breast cancer therapy
    Tanaka, Takemi
    Decuzzi, Paolo
    Cristofanilli, Massimo
    Sakamoto, Jason H.
    Tasciotti, Ennio
    Robertson, Fredika M.
    Ferrari, Mauro
    [J]. BIOMEDICAL MICRODEVICES, 2009, 11 (01) : 49 - 63
  • [9] A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer
    Jain, Vikas
    Kumar, Hitesh
    Anod, Haritha, V
    Chand, Pallavi
    Gupta, N. Vishal
    Dey, Surajit
    Kesharwani, Siddharth S.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2020, 326 (326) : 628 - 647
  • [10] Nanotechnology Applications in Breast Cancer Immunotherapy
    Wang, Ruijie
    Kumar, Pramod
    Reda, Moataz
    Wallstrum, Alyssa G.
    Crumrine, Noah A.
    Ngamcherdtrakul, Worapol
    Yantasee, Wassana
    [J]. SMALL, 2023, 20 (41)