P16 and HPV status in head and neck sarcomas and sarcomatoid carcinomas

被引：0
|
作者：
Shaker, Nuha [1 ,5 ]
Mansoori, Parisa [2 ]
Fattah, Yasmin H. [1 ]
Ellis, Monika [1 ]
Sexton, Tammy [3 ]
Neill, Stacey O. ' [3 ]
Qasem, Shadi A. [1 ,4 ]
机构：
[1] Univ Kentucky, Dept Pathol & Lab Med, Lexington, KY USA
[2] Pathgrp, Atlanta Dermatopathol, Atlanta, GA USA
[3] Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC USA
[4] Baptist Hlth, Jacksonville, FL USA
[5] Univ Pittsburgh, Med Ctr, 200 Lothrop St, Pittsburgh, PA 15213 USA
来源：
ANNALS OF DIAGNOSTIC PATHOLOGY | 2024年 / 71卷
关键词：
HPV; p16; Sarcomatoid; Spindle cell carcinoma; Sarcoma; Mesenchymal; SQUAMOUS-CELL CARCINOMA; EXPRESSION; TUMORS;
D O I：
10.1016/j.anndiagpath.2024.152307
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Human papillomavirus (HPV)-positive oropharyngeal carcinoma is a distinct type of head and neck carcinoma with improved prognosis. p16 immunostaining is often used as a surrogate marker for HPV infection in this particular setting. The aim of this study is to estimate the prevalence of p16 staining and HPV infection in head and neck sarcomatoid carcinomas as well as head and neck sarcomas. 21 sarcomatoid carcinomas and 28 head and neck sarcomas were tested for p16 positivity using immunohistochemical staining, and for high-risk HPV infection using In situ hybridization (ISH). 24 % of sarcomatoid carcinomas and 21 % of sarcomas were positive for p16 staining. All 49 cases were negative for HPV ISH. The results confirm that p16 staining is not specific and may not be associated with HPV infection in non-oropharyngeal head and neck sites. They also indicate that nonoropharyngeal head and neck sarcomatoid carcinomas are not likely to be HPV related.
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页数：5
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