Association between renal α-klotho and renal pathology among patients with chronic kidney disease

IntroductionThis study was designed to investigate whether renal alpha-klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD).MethodsWe conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And alpha-klotho expressions were assessed by RT-PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed.ResultsRenal alpha-klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy.ConclusionsThe renal alpha-klotho is related to renal pathology.