Association between renal α-klotho and renal pathology among patients with chronic kidney disease

被引：1

作者：

Guo, Yan ^{[1
,2
]}

Wan, Feng ^{[1
,2
]}

Shi, Yan-peng ^{[3
]}

Zhang, Hong-mei ^{[1
]}

Yang, Ru-chun ^{[1
,2
]}

机构：

[1] Zhejiang Chinese Med Univ, Hangzhou TCM Hosp, Hangzhou 310007, Zhejiang, Peoples R China

[2] Key Lab Kidney Dis Prevent & Control Technol, Hangzhou, Zhejiang, Peoples R China

[3] Linping Hosp Integrated Tradit Chinese & Western M, Hangzhou, Zhejiang, Peoples R China

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2024年 / 28卷 / 05期

基金：

中国国家自然科学基金;

关键词：

CKD patients; renal pathology; renal alpha-klotho; FIBROSIS; CONTRIBUTES; INJURY;

D O I：

10.1111/1744-9987.14165

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IntroductionThis study was designed to investigate whether renal alpha-klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD).MethodsWe conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And alpha-klotho expressions were assessed by RT-PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed.ResultsRenal alpha-klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy.ConclusionsThe renal alpha-klotho is related to renal pathology.

引用

页码：769 / 774

页数：6

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