USP24 suppresses T cell anti-tumor activity by enhancing the stability of the PD-1 protein

被引：0
|
作者：
Hsieh, Hung-Chia
Hung, Jan-Jong
Wang, Yi-Ching
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2024-LB445
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LB445
引用
收藏
页数：2
相关论文
共 50 条
  • [31] PD-1 silencing impairs the anti-tumor function of chimeric antigen receptor modified T cells by inhibiting proliferation activity
    Wei, Jianshu
    Luo, Can
    Wang, Yao
    Guo, Yelei
    Dai, Hanren
    Tong, Chuan
    Ti, Dongdong
    Wu, Zhiqiang
    Han, Weidong
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7 (01):
  • [32] Glutaminase inhibition with CB-839 enhances anti-tumor activity of PD-1 and PD-L1 antibodies by overcoming a metabolic checkpoint blocking T cell activation
    Gross, Matt
    Chen, Jason
    Engler, Judd
    Janes, Julie
    Leone, Robert
    MacKinnon, Andy
    Parlati, Francesco
    Rodriquez, Mirna
    Shwonek, Peter
    Powell, Jonathan
    CANCER RESEARCH, 2016, 76
  • [33] D-mannose targets PD-1 to lysosomal degradation and enhances T cell-mediated anti-tumor immunity
    Dong, Wenjing
    Lin, Mingen
    Zhang, Ruonan
    Sun, Xue
    Li, Hongchen
    Liu, Tianshu
    Xu, Yanping
    Lv, Lei
    CANCER LETTERS, 2024, 591
  • [34] SAA suppresses α-PD-1 induced anti-tumor immunity by driving TH2 polarization in lung adenocarcinoma
    Wang, Xin
    Wen, Shaodi
    Du, Xiaoyue
    Zhang, Yihan
    Yang, Xiao
    Zou, Renrui
    Feng, Bing
    Fu, Xiao
    Jiang, Feng
    Zhou, Guoren
    Liu, Zi
    Zhu, Wei
    Ma, Rong
    Feng, Jifeng
    Shen, Bo
    CELL DEATH & DISEASE, 2023, 14 (11)
  • [35] SAA suppresses α-PD-1 induced anti-tumor immunity by driving TH2 polarization in lung adenocarcinoma
    Xin Wang
    Shaodi Wen
    Xiaoyue Du
    Yihan Zhang
    Xiao Yang
    Renrui Zou
    Bing Feng
    Xiao Fu
    Feng Jiang
    Guoren Zhou
    Zi Liu
    Wei Zhu
    Rong Ma
    Jifeng Feng
    Bo Shen
    Cell Death & Disease, 14
  • [36] Anti-tumor activity of a novel anti-human PD-1 antibody BGB-A317 in mouse models
    Song, Xiaomin
    Tang, Zhiyu
    Zhang, Tong
    Guo, Mingming
    Gong, Wenfeng
    Liu, Yong
    Zhang, Ningning
    Zhang, Yilu
    Zhang, Yanjuan
    Ma, Jie
    Song, Jing
    Li, Kang
    Wang, Lai
    CANCER RESEARCH, 2016, 76
  • [37] ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy
    Li, Chunyang
    Li, Weiyun
    Xiao, Jun
    Jiao, Shaozhuo
    Teng, Fei
    Xue, Shengjie
    Zhang, Chi
    Sheng, Chun
    Leng, Qibin
    Rudd, Christopher E.
    Wei, Bin
    Wang, Hongyan
    EMBO MOLECULAR MEDICINE, 2015, 7 (06) : 754 - 769
  • [38] Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor
    Zhao, Jingjing
    Dong, Jiebin
    Deng, Changwen
    Zhang, Qianjing
    Sun, Shicheng
    Li, Honggang
    Bai, Yun
    Deng, Hongkui
    ONCOIMMUNOLOGY, 2023, 12 (01):
  • [39] PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor
    Ambler, Rachel
    Edmunds, Grace L.
    Tan, Sin Lih
    Cirillo, Silvia
    Pernes, Jane, I
    Ruan, Xiongtao
    Huete-Carrasco, Jorge
    Wong, Carissa C. W.
    Lu, Jiahe
    Ward, Juma
    Toti, Giulia
    Hedges, Alan J.
    Dovedi, Simon J.
    Murphy, Robert F.
    Morgan, David J.
    Wulfing, Christoph
    SCIENCE SIGNALING, 2020, 13 (649)
  • [40] Enhancing anti-tumor efficacy of MART-1-specific TCR-T cells by CRISPR-Cas9-based PD-1 disruption
    Gao, Qianqian
    Ding, Renpeng
    Chen, Huanyi
    Xu, Qumiao
    Zhu, Linnan
    Dong, Xuan
    Gu, Ying
    Chao, Cheng-chi
    CANCER RESEARCH, 2020, 80 (16)
12345