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Seasonal variation of HbA1c levels in diabetic and non-diabetic patients
被引:0
|作者:
Ahuja, Sana
[1
]
Sugandha, Sugandha
[2
]
Kumar, Rohit
[3
]
Zaheer, Sufian
[1
]
Singh, Mukul
[1
]
机构:
[1] Vardhman Mahavir Med Coll & Safdarjung Hosp, Dept Pathol, New Delhi, India
[2] GS Med Coll & Hosp, Dept Pathol, Hapur, Uttar Pradesh, India
[3] Vardhman Mahavir Med Coll & Safdarjung Hosp, Dept Pulm & Crit Care Med, New Delhi, India
关键词:
HbA1c;
Seasonal variation;
Diabetics;
Fasting blood glucose;
Glycated hemoglobin;
GLYCATED HEMOGLOBIN;
HBA(1C);
A1C;
CHILDREN;
GLUCOSE;
D O I:
10.1016/j.plabm.2024.e00396
中图分类号:
R446 [实验室诊断];
R-33 [实验医学、医学实验];
学科分类号:
1001 ;
摘要:
Background: Hemoglobin A1c (HbA1c) serves as a pivotal marker for long -term glycemic control. The Diabetes Control and Complications Trial (DCCT) established its relevance, yet gaps exist in understanding potential seasonal variations in HbA1c levels among diabetic patients. The study highlights the need to explore potential seasonal variations in HbA1c levels and their impact on diabetic patients. Materials and methods: This is an observational study conducted in a tertiary care hospital from January to December 2019, the study analyzed HbA1c levels in 8138 patients. Blood samples were collected using Potassium EDTA-containing vials and processed with an automated analyzer. Seasonal variations were explored using time series analysis. Results: Mean HbA1c levels peaked during the monsoon (June to September) and were lowest in autumn (October to November). Subgroup analysis revealed differences in patients with HbA1c values below and above 6.5 %. Those with controlled blood sugar showed higher levels in winter (December to February) and monsoon (June to September), while patients with HbA1c values >= 6.5 % exhibited significantly lower levels in monsoon (June to September) and autumn (October to November) compared to summer (March to May). Conclusion: In contrast to global trends, Indian patients demonstrated distinct seasonal variations in HbA1c levels. The highest levels during the monsoon (June to September) may be linked to reduced outdoor activity and dietary changes. The study emphasizes the need for tailored diabetes management considering seasonal influences. Further extensive, longitudinal studies across diverse Indian regions are recommended to comprehensively grasp the impact of seasonal changes on diabetes outcomes.
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