Mechanisms of acquired resistance to AKT inhibitor capivasertib in AKT1 mutant patient derived breast cancer models

被引:0
|
作者
Mearns, Sarah
Pearson, Alex
Sim, Li-Xuan
Cutts, Rosalind
Sritharan, Prithika
Shah, Heena
Gulati, Aditi
Williamson, Stuart
Barry, Simon
De-Bruin, Elza
Turner, Nicholas C.
机构
关键词
D O I
10.1158/1538-7445.AM2024-LB450
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LB450
引用
收藏
页数:2
相关论文
共 50 条
  • [41] BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models
    Politz, Oliver
    Siegel, Franziska
    Baerfacker, Lars
    Boemer, Ulf
    Haegebarth, Andrea
    Scott, William J.
    Michels, Martin
    Ince, Stuart
    Neuhaus, Roland
    Meyer, Kirstin
    Fernandez-Montalvan, Amaury Ernesto
    Liu, Ningshu
    von Nussbaum, Franz
    Mumberg, Dominik
    Ziegelbauer, Karl
    INTERNATIONAL JOURNAL OF CANCER, 2017, 140 (02) : 449 - 459
  • [42] Activation of Akt pathway and autophagy promotes resistance to FASN inhibition in colorectal cancer patient-derived xenograft models
    Zaytseva, Yekaterina Y.
    Rychahou, Piotr G.
    Le, Anh-Thu
    Flight, Robert M.
    Scott, Timothy L.
    Harris, Jennifer W.
    Hodges, Sally
    Hallahan, Brent J.
    Napier, Dana L.
    Liu, Jinpeng
    Wang, Chi
    Sunkara, Manjula
    Morris, Andrew
    Kim, Ji Tae
    Arumugam, Sivakumaran Theru
    Lane, Andrew
    Fan, Teresa W.
    Moseley, Hunter
    Gao, Tianyan
    Lee, Eun Y.
    Weiss, Heidi L.
    Heuer, Timothy S.
    Kemble, George
    Evers, B. Mark
    CANCER RESEARCH, 2017, 77
  • [43] AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
    Marina Riggio
    María C. Perrone
    María L. Polo
    María J. Rodriguez
    María May
    Martín Abba
    Claudia Lanari
    Virginia Novaro
    Scientific Reports, 7
  • [44] AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins
    Riggio, Marina
    Perrone, Maria C.
    Polo, Maria L.
    Rodriguez, Maria J.
    May, Maria
    Abba, Martin
    Lanari, Claudia
    Novaro, Virginia
    SCIENTIFIC REPORTS, 2017, 7
  • [45] The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer
    Anna Jia
    Yuexin Wang
    Yufei Wang
    Yan Li
    Qiuli Yang
    Yejin Cao
    Ying He
    Lin Dong
    Yingjie Dong
    Yueru Hou
    Ruoning Wang
    Yujing Bi
    Guangwei Liu
    Cellular & Molecular Immunology, 2021, 18 : 1074 - 1076
  • [46] The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer
    Jia, Anna
    Wang, Yuexin
    Wang, Yufei
    Li, Yan
    Yang, Qiuli
    Cao, Yejin
    He, Ying
    Dong, Lin
    Dong, Yingjie
    Hou, Yueru
    Wang, Ruoning
    Bi, Yujing
    Liu, Guangwei
    CELLULAR & MOLECULAR IMMUNOLOGY, 2021, 18 (04) : 1074 - 1076
  • [47] MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
    Thirumurthi, Umadevi
    Shen, Jia
    Xia, Weiya
    LaBaff, Adam M.
    Wei, Yongkun
    Li, Chia-Wei
    Chang, Wei-Chao
    Chen, Chung-Hsuan
    Lin, Hui-Kuan
    Yu, Dihua
    Hung, Mien-Chie
    SCIENCE SIGNALING, 2014, 7 (336)
  • [48] Virtual screening of polyherbal compounds for AKT1 and HSPB1 inhibition in breast cancer apoptosis pathway
    Wahyuningsih, Nadia
    Fatchiyah, Fatchiyah
    Turhadi, Turhadi
    Widodo, Nashi
    Rahayu, Sri
    Rifa'i, Muhaimin
    COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2025, 115
  • [49] Regulation of inflammatory breast cancer cell invasion through Akt1/PKBα phosphorylation of RhoC GTPase
    Lehman, H. L.
    Van Laere, S. J.
    van Golen, C. M.
    Vermeulen, P. B.
    Dirix, L. Y.
    van Golen, K. L.
    CANCER RESEARCH, 2012, 72
  • [50] Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKBα Phosphorylation of RhoC GTPase
    Lehman, Heather L.
    Van Laere, Steven J.
    van Golen, Cynthia M.
    Vermeulen, Peter B.
    Dirix, Luc Y.
    van Golen, Kenneth L.
    MOLECULAR CANCER RESEARCH, 2012, 10 (10) : 1306 - 1318