Visible-Light-Induced C-H Cyanoalkylation of Azauracils with Cycloketone Oxime Esters via Catalytic EDA Complex

被引：8
|
作者：
Huang, Xiao-Long [1 ]
Zhang, Dong-Liang [1 ]
Li, Qing [1 ]
Xie, Zong-Bo [1 ]
Le, Zhang-Gao [1 ]
Zhu, Zhi-Qiang [1 ]
机构：
[1] East China Univ Technol, Sch Chem & Mat Sci, Jiangxi Prov Key Lab Synthet Chem, Nanchang 330013, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 18期
关键词：
DONOR-ACCEPTOR COMPLEX; ALKYLATION; DRUG; BOND; TRIPHENYLPHOSPHINE;
D O I：
10.1021/acs.orglett.4c00742
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Photoexcitation electron donor-acceptor (EDA) complexes provide an effective approach to produce radicals under mild conditions, while the catalytic version of EDA complex photoactivation remains scarce. Herein, we report a visible-light-induced organophotocatalytic pathway for the cyanoalkylation of azauracils using inexpensive and readily available 1,4-diazabicyclo[2.2.2]octane (DABCO) as a catalytic electron donor. This synthetic method exhibits exceptional compatibility with various functional groups and presents 34 examples in high yields. The efficient cyanoalkylation offers an environmentally friendly and sustainable route toward enhancing the structural and functional diversity of azauracils.
引用
收藏
页码：3727 / 3732
页数：6
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