Potential of Milk-Derived Extracellular Vesicles as Carriers for Oral Delivery of Active Phytoconstituents

被引:2
|
作者
Jiang, Qiao [1 ]
Liu, Yubo [1 ]
Si, Xu [1 ]
Wang, Li [2 ]
Gui, Hailong [1 ]
Tian, Jinlong [1 ]
Cui, Huijun [1 ]
Jiang, Hongzhou [3 ]
Dong, Wenjiang [4 ]
Li, Bin [1 ]
机构
[1] Shenyang Agr Univ, Coll Food Sci, Shenyang, Peoples R China
[2] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China
[3] Anhui Ziyue Biol Technol Co Ltd, Wuhu, Peoples R China
[4] Chinese Acad Trop Agr Sci, Spice & Beverage Res Inst, Wanning, Peoples R China
关键词
milk; extracellular vesicles; nanocarriers; oral delivery; active phytoconstituents; bioavailability; STEM-CELLS; EXOSOMAL FORMULATION; QUANTITATIVE CHANGES; PARKINSONS-DISEASE; HUMAN DIGESTION; MESSENGER-RNA; BREAST-MILK; BOVINE; MICRORNAS; NANOFORMULATIONS;
D O I
10.1146/annurev-food-072023-034354
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Extracellular vesicles (EVs) play a crucial role in intercellular communication and have the potential to serve as in vivo carriers for delivering active molecules. The biocompatibility advantages of EVs over artificial nanocarriers create new frontiers for delivering modern active molecules. Milk is a favorable source of EVs because of its high bioavailability, low immunogenicity, and commercial producibility. In this review, we analyzed the advantages of milk-derived EVs in the oral delivery of active molecules, discussed their research progress in delivering active phytoconstituents, and summarized the necessary technologies and critical unit operations required for the development of an oral delivery system based on EVs. The review aims to provide innovative ideas and fundamental quality control guidelines for developing the next-generation oral drug delivery system based on milk-derived EVs.
引用
收藏
页码:431 / 454
页数:24
相关论文
共 50 条
  • [31] Comparison of miRNA profiles in milk-derived extracellular vesicles and bovine mammary glands
    Li, Wenqing
    Li, Wanli
    Wang, Xiaoyang
    Zhang, Honglu
    Wang, Linfeng
    Gao, Tengyun
    [J]. INTERNATIONAL DAIRY JOURNAL, 2022, 134
  • [32] Harnessing the power of goat milk-derived extracellular vesicles for medical breakthroughs: A review
    Meng, Yiming
    Sun, Jing
    Zhang, Guirong
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 262
  • [33] Bovine Milk-Derived Extracellular Vesicles as a Novel Injury-Targeting Drug Delivery System Following Cardiac Injury
    Marsh, Spencer R.
    Jourdan, Jane
    Gourdie, Robert G.
    [J]. CIRCULATION, 2022, 146
  • [34] Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis
    Pisano, Courtney
    Galley, Jeffrey
    Elbahrawy, Mostafa
    Wang, Yijie
    Farrell, Aidan
    Brigstock, David
    Besner, Gail E.
    [J]. JOURNAL OF PEDIATRIC SURGERY, 2020, 55 (01) : 54 - 58
  • [35] Oral Milk-Derived Extracellular Vesicles Inhibit Osteoclastogenesis and Ameliorate Bone Loss in Ovariectomized Mice by Improving Gut Microbiota
    Hao, Haining
    Liu, Qiqi
    Zheng, Ting
    Li, Jiankun
    Zhang, Tai
    Yao, Yukun
    Liu, Yisuo
    Lin, Kai
    Liu, Tongjie
    Gong, Pimin
    Zhang, Zhe
    Yi, Huaxi
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (09) : 4726 - 4736
  • [36] Oral Delivery of Photoresponsive Milk-Derived Exosomes for the Local Therapy of Glioblastoma
    Choi, Jiwoong
    Jang, Hochung
    Park, Daeho
    Park, Byeongmin
    Jang, Yeongji
    Lee, Sangmin
    Kim, Sun Hwa
    Shim, Man Kyu
    Yang, Yoosoo
    [J]. ACS MATERIALS LETTERS, 2024, 6 (09): : 4019 - 4027
  • [37] Complexity of the microRNA transcriptome of cow milk and milk-derived extracellular vesicles isolated via differential ultracentrifugation
    Benmoussa, Abderrahim
    Laugier, Jonathan
    Beauparlant, Charles Joly
    Lambert, Marine
    Droit, Arnaud
    Provost, Patrick
    [J]. JOURNAL OF DAIRY SCIENCE, 2020, 103 (01) : 16 - 29
  • [38] A Comparison of Different Methodologies for the Measurement of Extracellular Vesicles and Milk-derived Particles in Raw Milk from Cows
    Pollott, Geoff
    Brito, Amanda
    Gardiner, Christopher
    Lawson, Charlotte
    [J]. BIOMARKER INSIGHTS, 2016, 11 : 147 - 155
  • [39] Milk-derived small extracellular vesicles promote bifidobacteria growth by accelerating carbohydrate metabolism
    Luo, Yujia
    Bi, Jintian
    Lin, Yingying
    He, Jian
    Wu, Shan
    Zhang, Yuning
    Wang, Yuqi
    Song, Sijia
    Guo, Huiyuan
    [J]. LWT-FOOD SCIENCE AND TECHNOLOGY, 2023, 182
  • [40] Skimmed Bovine Milk-Derived Extracellular Vesicles Isolated via "Salting-Out": Characterizations and Potential Functions as Nanocarriers
    Tan, Xiao-Hui
    Fang, Dong
    Xu, Yong-De
    Nan, Tie-Gui
    Song, Wen-Peng
    Gu, Yang-Yang
    Gu, Sheng-Ji
    Yuan, Yi-Ming
    Xin, Zhong-Cheng
    Zhou, Li-Qun
    Guan, Rui-Li
    Li, Xue-Song
    [J]. FRONTIERS IN NUTRITION, 2021, 8