Effect of Oridonin on Experimental Animal Model of Bronchopulmonary Dysplasia

被引：1

作者：

Zhang, Shanshan ^{[1
]}

Wang, Junfu ^{[2
]}

Xin, Zhihong ^{[3
]}

Sun, Chao ^{[4
]}

Ju, Zhiye ^{[5
]}

Xue, Xia ^{[6
]}

Jiang, Wen ^{[4
]}

Xin, Qian ^{[4
]}

Wang, Jue ^{[4
]}

Zhang, Zhaohua ^{[3
]}

Luan, Yun ^{[4
,7
]}

机构：

[1] Shandong Univ, Hosp 2, Dept Emergency, Jinan, Peoples R China

[2] Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Hosp 2, Dept Obstet, Jinan, Shandong, Peoples R China

[4] Shandong Univ, Inst Med Sci, Hosp 2, Jinan, Peoples R China

[5] Shandong Prov Publ Hlth Clin Ctr, Dept Ultrasound, Jinan, Peoples R China

[6] Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Pharm, Jinan, Shandong, Peoples R China

[7] Shandong Univ, Hosp 2, Renal Multidisciplinary Innovat Med Ctr, Jinan, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2024年 / 125卷 / 09期

基金：

中国国家自然科学基金;

关键词：

bronchopulmonary dysplasia; hyperoxia; inflammatory; oridonin; ALVEOLAR EPITHELIAL-CELLS;

D O I：

10.1002/jcb.30632

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bronchopulmonary dysplasia (BPD) is a serious disease that occurs in premature and low-birth-weight infants. In recent years, the incidence of BPD has not decreased, and there is no effective treatment for it. Oridonin (Ori) is a traditional Chinese medicine with a wide range of biological activities, especially pharmacological and anti-inflammatory. It is well known that inflammation plays a key role in BPD. However, the therapeutic effect of Ori on BPD has not been studied. Therefore, in the present study, we will observe the anti-inflammatory activity of Ori in an experimental animal model of BPD. Here, we showed that Ori could significantly decrease hyperoxia-induced alveolar injury, inhibit neutrophil recruitment, myeloperoxidase concentrations, and release inflammatory factors in BPD neonatal rats. Taken together, the experimental results suggested that Ori can significantly improve BPD in neonatal rats by inhibiting inflammatory response.

引用

页数：8

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