Oocyte Maturation and miRNAs: Studying a Complicate Interaction to Reveal Possible Biomarkers for Female Infertility

被引：2

作者：

Nazou, Eleni ^{[1
]}

Potiris, Anastasios ^{[1
]}

Mavrogianni, Despoina ^{[2
]}

Drakaki, Eirini ^{[2
]}

Vogiatzis, Aris-Anargyros ^{[1
]}

Sarli, Vaia ^{[1
]}

Vrantza, Tereza ^{[1
]}

Zikopoulos, Athanasios ^{[1
]}

Louis, Konstantinos ^{[1
]}

Skentou, Chara ^{[3
]}

Panagopoulos, Periklis ^{[1
]}

Drakakis, Peter ^{[1
]}

Stavros, Sofoklis ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Univ Gen Hosp ATTIKON, Med Sch, Dept Obstet & Gynecol 3, Athens 12462, Greece

[2] Natl & Kapodistrian Univ Athens, Alexandra Hosp, Med Sch, Dept Obstet & Gynecol 1, Athens 11528, Greece

[3] Univ Ioannina, Med Sch, Dept Obstet & Gynecol, Ioannina 45110, Greece

来源：

DISEASES | 2024年 / 12卷 / 06期

关键词：

microRNAs (miRNAs); infertility; granulosa cells; cumulus cells; Dicer; GRANULOSA-CELL APOPTOSIS; FOLLICULAR-FLUID; IN-VITRO; EXOSOMAL MICRORNAS; DICER; EXPRESSION; GENE; IDENTIFICATION; PROLIFERATION; FERTILIZATION;

D O I：

10.3390/diseases12060121

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cellular metabolism, apoptosis, fertilization, and proliferation of granulosa cells belong to a battery of processes where microRNAs can be detected and associated with infertility. The aim of the present review is to focus on mammalian oocyte maturation events and the association between oocyte growth and miRNA expression. PubMed/Medline, Google Scholar and Scopus databases were searched, and 33 studies were included. Regarding the correlation among miRNA expression and the regulation of granulosa cells and cumulus cells, the most important miRNAs were let-7b, let-7c and miR-21. Additionally, the loss of Dicer, an enzyme involved in miRNA biogenesis, is probably a crucial factor in oogenesis, oocyte maturation and embryogenesis. Furthermore, miRNAs interfere with different cellular mechanisms like apoptosis, steroidogenesis, genome integrity, angiogenesis, antioxidative response and, consequently, oocyte maturation. Hence, it is of major importance to clarify the role and mechanism of each miRNA as understanding its action may develop new tools and establish new diagnostic and treatment approaches for infertility and ovarian disorders.

引用

页数：10

共 34 条

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