Total Synthesis enabled by Epimerization with Hydrogen Atom Transfer

被引：0
|
作者：
Okamura, Toshitaka
机构：
来源：
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2024年 / 82卷 / 04期
关键词：
All Open Access; Bronze;
D O I：
10.5059/yukigoseikyokaishi.82.377
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the synthesis of natural products, epimerization serves as a powerful tool when undesired stereochemistry is obtained. This short review introduces the total synthesis of Securinine alkaloids and Pleurotin utilizing epimerization through hydrogen atom transfer(HAT)reaction with photoredox catalysts, reported by Han group and Sorensen group. HAT enable epimerization at untraditional positions, as they proceed dependently on the bond dissociation energy of C-H bonds.
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页码：377 / 378
页数：2
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