The case for therapeutic overactivation of oncogenic signaling as a potential cancer treatment strategy

被引：4
|
作者：
Dias, Matheus Henrique [1 ]
Papagianni, Chrysa [1 ]
Bernards, Rene [1 ]
机构：
[1] Netherlands Canc Inst, Oncode Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands
来源：
CANCER CELL | 2024年 / 42卷 / 06期
关键词：
D O I：
10.1016/j.ccell.2024.04.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Most targeted cancer drugs inhibit the oncogenic signals to which cancer cells are addicted. We discuss here a counterintuitive approach to cancer therapy, which consists of deliberate overactivation of the oncogenic signals to overload the stress responses of cancer cells. We discuss why such overactivation of oncogenic signaling, combined with perturbation of the stress response pathways, can be potentially effective in killing cancer cells, aiming to inspire further discussion and consideration.
引用
收藏
页码：919 / 922
页数：4
相关论文
共 50 条
  • [31] Therapeutic strategies for inhibiting oncogenic BRAF signaling
    Halilovic, Ensar
    Solit, David B.
    CURRENT OPINION IN PHARMACOLOGY, 2008, 8 (04) : 419 - 426
  • [32] Therapeutic potential of melatonin in cancer treatment
    Abrial, C
    Kwaitkowski, F
    Chevrier, R
    Gachon, F
    Curé, H
    Chollet, P
    PATHOLOGIE BIOLOGIE, 2005, 53 (05): : 265 - 268
  • [33] The therapeutic potential of andrographolide in cancer treatment
    Hu, Jiaxuan
    Li, Yi
    Xie, Xin
    Song, Yunlei
    Yan, Wenjing
    Luo, Yan
    Jiang, Yumao
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 180
  • [34] Complex adaptive therapeutic strategy for cancer treatment
    Park, Kinam
    JOURNAL OF CONTROLLED RELEASE, 2014, 175 : 87 - 87
  • [35] Purinergic signaling: Diverse effects and therapeutic potential in cancer
    Kaur, Jasmeet
    Dora, Sanchit
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [36] Notch Signaling: A Potential Therapeutic Target in Prostate Cancer
    Villaronga, M. A.
    Bevan, C. L.
    Belandia, B.
    CURRENT CANCER DRUG TARGETS, 2008, 8 (07) : 566 - 580
  • [37] Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer
    Cong, Ge
    Zhu, Xingyu
    Chen, Xin Ru
    Chen, Hao
    Chong, Wei
    CELL DEATH DISCOVERY, 2025, 11 (01)
  • [38] Wnt signaling as potential therapeutic target in lung cancer
    Yang, Jiali
    Chen, Juan
    He, Jinxi
    Li, Jing
    Shi, Juan
    Cho, William C.
    Liu, Xiaoming
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2016, 20 (08) : 999 - 1015
  • [39] Targeting Autophagy As a Potential Therapeutic Strategy for the Treatment of AML
    Folkerts, Hendrik
    Wierenga, Bart-Jan A. T. J.
    Coffer, Paul J.
    Schuringa, Jan Jacob
    Vellenga, Edo
    BLOOD, 2015, 126 (23)
  • [40] Iron chelation: a potential therapeutic strategy in oesophageal cancer
    Keeler, B. D.
    Brookes, M. J.
    BRITISH JOURNAL OF PHARMACOLOGY, 2013, 168 (06) : 1313 - 1315
12345