The case for therapeutic overactivation of oncogenic signaling as a potential cancer treatment strategy

被引：4

作者：

Dias, Matheus Henrique ^{[1
]}

Papagianni, Chrysa ^{[1
]}

Bernards, Rene ^{[1
]}

机构：

[1] Netherlands Canc Inst, Oncode Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands

来源：

CANCER CELL | 2024年 / 42卷 / 06期

关键词：

D O I：

10.1016/j.ccell.2024.04.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most targeted cancer drugs inhibit the oncogenic signals to which cancer cells are addicted. We discuss here a counterintuitive approach to cancer therapy, which consists of deliberate overactivation of the oncogenic signals to overload the stress responses of cancer cells. We discuss why such overactivation of oncogenic signaling, combined with perturbation of the stress response pathways, can be potentially effective in killing cancer cells, aiming to inspire further discussion and consideration.

引用

页码：919 / 922

页数：4

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